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    Ncan neurocan [ Mus musculus (house mouse) ]

    Gene ID: 13004, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ncanprovided by MGI
    Official Full Name
    neurocanprovided by MGI
    Primary source
    MGI:MGI:104694
    See related
    Ensembl:ENSMUSG00000002341 AllianceGenome:MGI:104694
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cspg3; Tgfbit; Cspg3-rs; C230035B04
    Summary
    Predicted to enable calcium ion binding activity; carbohydrate binding activity; and hyaluronic acid binding activity. Involved in modulation of chemical synaptic transmission and regulation of postsynapse organization. Acts upstream of or within regulation of synapse structural plasticity. Is active in GABA-ergic synapse; glutamatergic synapse; and perisynaptic extracellular matrix. Is expressed in lower jaw; nervous system; and sensory organ. Orthologous to human NCAN (neurocan). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in whole brain E14.5 (RPKM 31.9), CNS E18 (RPKM 28.5) and 6 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ncan in Genome Data Viewer
    Location:
    8 B3.3; 8 34.15 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (70545735..70573494, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (70093085..70120863, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene transmembrane 6 superfamily member 2 Neighboring gene hyaluronan and proteoglycan link protein 4 Neighboring gene microRNA 7066 Neighboring gene predicted gene, 25906 Neighboring gene nuclear receptor 2C2-associated protein Neighboring gene regulatory factor X-associated ankyrin-containing protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables hyaluronic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in glutamatergic synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in perineuronal net IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in perineuronal net ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in perisynaptic extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    neurocan core protein
    Names
    TGFbeta-induced transcript, brain
    chondroitin sulfate proteoglycan 3, related sequence

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007789.3NP_031815.2  neurocan core protein precursor

      See identical proteins and their annotated locations for NP_031815.2

      Status: VALIDATED

      Source sequence(s)
      BC065118, BQ745524, CX202471
      Consensus CDS
      CCDS22358.1
      UniProtKB/Swiss-Prot
      P55066, Q6P1E3, Q8C4F8
      UniProtKB/TrEMBL
      A0A0R4IZX5
      Related
      ENSMUSP00000002412.9, ENSMUST00000002412.9
      Conserved Domains (7) summary
      cd00033
      Location:11671224
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cd00054
      Location:9981034
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd03517
      Location:159253
      Link_domain_CSPGs_modules_1_3; Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: ...
      cd03520
      Location:260355
      Link_domain_CSPGs_modules_2_4; Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The ...
      pfam00008
      Location:964994
      EGF; EGF-like domain
      cl02432
      Location:10401163
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
      cl11960
      Location:50160
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      70545735..70573494 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)