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    Marchf1 membrane associated ring-CH-type finger 1 [ Mus musculus (house mouse) ]

    Gene ID: 72925, updated on 9-Dec-2024

    Summary

    Official Symbol
    Marchf1provided by MGI
    Official Full Name
    membrane associated ring-CH-type finger 1provided by MGI
    Primary source
    MGI:MGI:1920175
    See related
    Ensembl:ENSMUSG00000036469 AllianceGenome:MGI:1920175
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    March1; 2900024D24Rik
    Summary
    Enables ubiquitin protein ligase activity. Involved in antigen processing and presentation of peptide antigen via MHC class II; immune response; and protein polyubiquitination. Located in bounding membrane of organelle; endoplasmic reticulum membrane; and trans-Golgi network membrane. Is expressed in brain; glossopharyngeal ganglion; and spinal cord. Orthologous to human MARCHF1 (membrane associated ring-CH-type finger 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E18 (RPKM 3.6), spleen adult (RPKM 2.6) and 17 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Marchf1 in Genome Data Viewer
    Location:
    8 B3.1; 8 33.06 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (66070558..66925761)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (65618009..66472841)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_21657 Neighboring gene STARR-seq mESC enhancer starr_21658 Neighboring gene STARR-seq mESC enhancer starr_21659 Neighboring gene predicted gene 7624 Neighboring gene vault RNA component pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_21660 Neighboring gene STARR-seq mESC enhancer starr_21661 Neighboring gene STARR-seq mESC enhancer starr_21663 Neighboring gene STARR-seq mESC enhancer starr_21664 Neighboring gene predicted gene, 23515 Neighboring gene STARR-seq mESC enhancer starr_21665 Neighboring gene STARR-seq mESC enhancer starr_21666 Neighboring gene ribosomal protein, large, P0 pseudogene Neighboring gene STARR-seq mESC enhancer starr_21667 Neighboring gene predicted gene, 26123 Neighboring gene predicted gene, 24205 Neighboring gene STARR-seq mESC enhancer starr_21668 Neighboring gene STARR-seq mESC enhancer starr_21669 Neighboring gene STARR-seq mESC enhancer starr_21670 Neighboring gene STARR-seq mESC enhancer starr_21671 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:69010363-69010546 Neighboring gene STARR-seq mESC enhancer starr_21673 Neighboring gene predicted gene, 32568 Neighboring gene translation machinery associated 16

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (1)  1 citation

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MHC protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables MHC protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables MHC protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in early endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in early endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in late endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in late endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in late endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in trans-Golgi network membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase MARCHF1
    Names
    E3 ubiquitin-protein ligase MARCH1
    MARCH-I
    RING-type E3 ubiquitin transferase MARCH1
    RING-type E3 ubiquitin transferase MARCHF1
    membrane-associated RING finger protein 1
    membrane-associated RING-CH protein I
    membrane-associated ring finger (C3HC4) 1
    NP_001159844.1
    NP_001159847.1
    NP_001280713.1
    NP_001350052.1
    NP_001350053.1
    NP_001350054.1
    NP_001390802.1
    NP_001390803.1
    NP_001390804.1
    NP_001390805.1
    NP_001390806.1
    NP_001390807.1
    NP_001390808.1
    NP_001390809.1
    NP_001390810.1
    NP_001390811.1
    NP_001390812.1
    NP_001390813.1
    NP_001390814.1
    NP_001390815.1
    NP_001390816.1
    NP_001390818.1
    NP_001390823.1
    NP_780397.2
    XP_006509817.1
    XP_006509818.1
    XP_030099653.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166372.2NP_001159844.1  E3 ubiquitin-protein ligase MARCHF1 isoform 1

      See identical proteins and their annotated locations for NP_001159844.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR and uses an alternate in-frame splice junction in the 3' coding sequence compared to variant 4. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform 4.
      Source sequence(s)
      AC114634, AC117251, AC122800, AC131655, AC140272
      Consensus CDS
      CCDS52560.1
      UniProtKB/Swiss-Prot
      Q6NZQ8
      Related
      ENSMUSP00000105884.2, ENSMUST00000110255.8
      Conserved Domains (1) summary
      cd16698
      Location:79130
      RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins
    2. NM_001166375.1NP_001159847.1  E3 ubiquitin-protein ligase MARCHF1 isoform 2

      See identical proteins and their annotated locations for NP_001159847.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction in the 3' coding sequence compared to variant 4. The resulting isoform (2) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 4.
      Source sequence(s)
      AK137337, AK152592, BB126406, BE686288, BM943350
      Consensus CDS
      CCDS52561.1
      UniProtKB/Swiss-Prot
      Q6NZQ8
      Conserved Domains (1) summary
      smart00744
      Location:69117
      RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins
    3. NM_001293784.2NP_001280713.1  E3 ubiquitin-protein ligase MARCHF1 isoform 4

      See identical proteins and their annotated locations for NP_001280713.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) encodes isoform 4.
      Source sequence(s)
      AC114634, AC117251, AC122800, AC131655, AC139159, AC140272
      Consensus CDS
      CCDS80884.1
      UniProtKB/Swiss-Prot
      Q3U7M8, Q3UVF8, Q6NZQ8, Q8C294, Q8CBA1
      Conserved Domains (2) summary
      smart00744
      Location:79127
      RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins
      pfam15245
      Location:40102
      VGLL4; Transcription cofactor vestigial-like protein 4
    4. NM_001363123.2NP_001350052.1  E3 ubiquitin-protein ligase MARCHF1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 4.
      Source sequence(s)
      AC117251, AC122800, AC131655, AC139159, AC140272
      Consensus CDS
      CCDS22333.1
      Conserved Domains (1) summary
      cd16698
      Location:75126
      RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins
    5. NM_001363124.2NP_001350053.1  E3 ubiquitin-protein ligase MARCHF1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) uses an alternate in-frame splice junction compared to variant 4.
      Source sequence(s)
      AC114634, AC117251, AC122800, AC131655, AC139159, AC140272
      Consensus CDS
      CCDS52560.1
      Conserved Domains (1) summary
      cd16698
      Location:79130
      RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins
    6. NM_001363125.2NP_001350054.1  E3 ubiquitin-protein ligase MARCHF1 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction compared to variant 4. The resulting isoform (5) differs in the N-terminus and lacks an alternate internal segment compared to isoform 4.
      Source sequence(s)
      AC117251, AC122800, AC131655, AC139159, AC140272
      Conserved Domains (1) summary
      cd16698
      Location:75126
      RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins
    7. NM_001403873.1NP_001390802.1  E3 ubiquitin-protein ligase MARCHF1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC114634, AC122800, AC139159, AC140272
      UniProtKB/TrEMBL
      D3YVY0
      Related
      ENSMUSP00000105885.2, ENSMUST00000110256.8
    8. NM_001403874.1NP_001390803.1  E3 ubiquitin-protein ligase MARCHF1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC117251, AC122800, AC131655, AC139159, AC140272
    9. NM_001403875.1NP_001390804.1  E3 ubiquitin-protein ligase MARCHF1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC122800, AC139159, AC140272
    10. NM_001403876.1NP_001390805.1  E3 ubiquitin-protein ligase MARCHF1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC114634, AC122800, AC139159, AC140272
    11. NM_001403877.1NP_001390806.1  E3 ubiquitin-protein ligase MARCHF1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC122800, AC139159, AC140272
    12. NM_001403878.1NP_001390807.1  E3 ubiquitin-protein ligase MARCHF1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC114634, AC117251, AC122800, AC131655, AC139159, AC140272
    13. NM_001403879.1NP_001390808.1  E3 ubiquitin-protein ligase MARCHF1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC114634, AC117251, AC122800, AC131655, AC140272
      UniProtKB/Swiss-Prot
      Q3U7M8, Q3UVF8, Q6NZQ8, Q8C294, Q8CBA1
      Related
      ENSMUSP00000136545.2, ENSMUST00000178982.8
    14. NM_001403880.1NP_001390809.1  E3 ubiquitin-protein ligase MARCHF1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC114634, AC117251, AC122800, AC131655, AC139159, AC140272
      UniProtKB/Swiss-Prot
      Q3U7M8, Q3UVF8, Q6NZQ8, Q8C294, Q8CBA1
    15. NM_001403881.1NP_001390810.1  E3 ubiquitin-protein ligase MARCHF1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC114634, AC122800, AC139159, AC140272
      UniProtKB/Swiss-Prot
      Q3U7M8, Q3UVF8, Q6NZQ8, Q8C294, Q8CBA1
    16. NM_001403882.1NP_001390811.1  E3 ubiquitin-protein ligase MARCHF1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC114634, AC122800, AC139159, AC140272
      UniProtKB/Swiss-Prot
      Q3U7M8, Q3UVF8, Q6NZQ8, Q8C294, Q8CBA1
    17. NM_001403883.1NP_001390812.1  E3 ubiquitin-protein ligase MARCHF1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC122800, AC139159, AC140272
    18. NM_001403884.1NP_001390813.1  E3 ubiquitin-protein ligase MARCHF1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC122800, AC139159, AC140272
      Related
      ENSMUSP00000072302.7, ENSMUST00000072482.13
    19. NM_001403885.1NP_001390814.1  E3 ubiquitin-protein ligase MARCHF1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC114634, AC122800, AC139159, AC140272
    20. NM_001403886.1NP_001390815.1  E3 ubiquitin-protein ligase MARCHF1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC117251, AC122800, AC131655, AC139159, AC140272
    21. NM_001403887.1NP_001390816.1  E3 ubiquitin-protein ligase MARCHF1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC122800, AC139159, AC140272
    22. NM_001403889.1NP_001390818.1  E3 ubiquitin-protein ligase MARCHF1 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC122800
      Related
      ENSMUSP00000105882.3, ENSMUST00000110253.3
    23. NM_001403894.1NP_001390823.1  E3 ubiquitin-protein ligase MARCHF1 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC122800
      Related
      ENSMUSP00000044070.6, ENSMUST00000039540.12
    24. NM_175188.5NP_780397.2  E3 ubiquitin-protein ligase MARCHF1 isoform 3

      See identical proteins and their annotated locations for NP_780397.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate first exon and lacks an alternate internal exon compared to variant 4. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 4.
      Source sequence(s)
      AC117251, AC122800, AC131655, AC139159, AC140272
      Consensus CDS
      CCDS22333.1
      UniProtKB/Swiss-Prot
      Q6NZQ8
      Related
      ENSMUSP00000105888.2, ENSMUST00000110259.8
      Conserved Domains (1) summary
      cd16698
      Location:75126
      RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      66070558..66925761
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243793.2XP_030099653.1  E3 ubiquitin-protein ligase MARCHF1 isoform X5

      Conserved Domains (1) summary
      cd16698
      Location:75126
      RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins
    2. XM_006509754.5XP_006509817.1  E3 ubiquitin-protein ligase MARCHF1 isoform X1

      Conserved Domains (1) summary
      cd16698
      Location:243294
      RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins
    3. XM_006509755.3XP_006509818.1  E3 ubiquitin-protein ligase MARCHF1 isoform X2

      Conserved Domains (1) summary
      cd16698
      Location:243294
      RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins