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    Farsa phenylalanyl-tRNA synthetase, alpha subunit [ Mus musculus (house mouse) ]

    Gene ID: 66590, updated on 9-Dec-2024

    Summary

    Official Symbol
    Farsaprovided by MGI
    Official Full Name
    phenylalanyl-tRNA synthetase, alpha subunitprovided by MGI
    Primary source
    MGI:MGI:1913840
    See related
    Ensembl:ENSMUSG00000003808 AllianceGenome:MGI:1913840
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    pheRS; Farsla; 0610012A19Rik
    Summary
    Predicted to enable magnesium ion binding activity and phenylalanine-tRNA ligase activity. Predicted to be involved in phenylalanyl-tRNA aminoacylation and protein heterotetramerization. Predicted to be part of phenylalanine-tRNA ligase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; heart; integumental system; and respiratory system. Orthologous to human FARSA (phenylalanyl-tRNA synthetase subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in liver E14.5 (RPKM 34.6), whole brain E14.5 (RPKM 32.7) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Farsa in Genome Data Viewer
    Location:
    8 C3; 8 41.23 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (85583597..85595886)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (84856969..84869257)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700122E12 gene Neighboring gene STARR-positive B cell enhancer ABC_E564 Neighboring gene calreticulin Neighboring gene predicted gene 5911 Neighboring gene STARR-positive B cell enhancer ABC_E11391 Neighboring gene microRNA 7069 Neighboring gene synaptonemal complex central element protein 2 Neighboring gene glutaryl-Coenzyme A dehydrogenase Neighboring gene STARR-positive B cell enhancer ABC_E1763 Neighboring gene predicted gene, 39213

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables magnesium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables phenylalanine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phenylalanine-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phenylalanine-tRNA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in phenylalanyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phenylalanyl-tRNA aminoacylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phenylalanyl-tRNA aminoacylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein heterotetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein heterotetramerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of phenylalanine-tRNA ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of phenylalanine-tRNA ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of phenylalanine-tRNA ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    phenylalanine--tRNA ligase alpha subunit
    Names
    phenylalanine--tRNA ligase alpha chain
    phenylalanine-tRNA synthetase-like, alpha subunit
    phenylalanyl-tRNA synthetase alpha chain
    NP_079924.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025648.3NP_079924.2  phenylalanine--tRNA ligase alpha subunit

      See identical proteins and their annotated locations for NP_079924.2

      Status: VALIDATED

      Source sequence(s)
      AK002577, AK031697, BB853717, BP754226
      Consensus CDS
      CCDS22480.2
      UniProtKB/Swiss-Prot
      Q3U3Q9, Q8C0C7, Q91WR4, Q922S1
      UniProtKB/TrEMBL
      E9PWY9
      Related
      ENSMUSP00000003906.7, ENSMUST00000003906.13
      Conserved Domains (2) summary
      PLN02853
      Location:22497
      PLN02853; Probable phenylalanyl-tRNA synthetase alpha chain
      pfam01409
      Location:209482
      tRNA-synt_2d; tRNA synthetases class II core domain (F)

    RNA

    1. NR_152751.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC155163, AC161765
      Related
      ENSMUST00000156970.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      85583597..85595886
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_004934868.1 RNA Sequence

    2. XR_004934867.1 RNA Sequence

    3. XR_387772.5 RNA Sequence

      Related
      ENSMUST00000129595.8