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    Mau2 MAU2 sister chromatid cohesion factor [ Mus musculus (house mouse) ]

    Gene ID: 74549, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mau2provided by MGI
    Official Full Name
    MAU2 sister chromatid cohesion factorprovided by MGI
    Primary source
    MGI:MGI:1921799
    See related
    Ensembl:ENSMUSG00000031858 AllianceGenome:MGI:1921799
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mau-2; mKIAA0892; 9130404D08Rik; A930019L04Rik
    Summary
    Predicted to enable cohesin loader activity and double-stranded DNA binding activity. Predicted to be involved in maintenance of mitotic sister chromatid cohesion. Located in chromatin. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human MAU2 (MAU2 sister chromatid cohesion factor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 37.4), ovary adult (RPKM 33.2) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Mau2 in Genome Data Viewer
    Location:
    8 B3.3; 8 34.15 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (70465896..70495384, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (70014527..70042734, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene GATA zinc finger domain containing 2A Neighboring gene STARR-positive B cell enhancer ABC_E5012 Neighboring gene STARR-positive B cell enhancer ABC_E1367 Neighboring gene STARR-seq mESC enhancer starr_21753 Neighboring gene STARR-seq mESC enhancer starr_21758 Neighboring gene STARR-positive B cell enhancer ABC_E89 Neighboring gene STARR-seq mESC enhancer starr_21762 Neighboring gene nucleoside diphosphate kinase B pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9314 Neighboring gene SURP and G patch domain containing 1 Neighboring gene transmembrane 6 superfamily member 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0892, MGC159271

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cohesin loader activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in maintenance of mitotic sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in maintenance of mitotic sister chromatid cohesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in maintenance of mitotic sister chromatid cohesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitotic sister chromatid cohesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic sister chromatid cohesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of SMC loading complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of SMC loading complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of SMC loading complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of Scc2-Scc4 cohesin loading complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Scc2-Scc4 cohesin loading complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    MAU2 chromatid cohesion factor homolog
    Names
    Scc4-like protein
    cohesin loading complex subunit SCC4 homolog
    protein MAU-2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001167939.2NP_001161411.1  MAU2 chromatid cohesion factor homolog isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC167132
      Consensus CDS
      CCDS85550.1
      UniProtKB/TrEMBL
      A0A1D5RLR7
      Related
      ENSMUSP00000148479.2, ENSMUST00000212308.2
      Conserved Domains (3) summary
      sd00006
      Location:71100
      TPR; TPR repeat [structural motif]
      pfam10345
      Location:30576
      Cohesin_load; Cohesin loading factor
      pfam14559
      Location:86157
      TPR_19; Tetratricopeptide repeat
    2. NM_001376946.1NP_001363875.1  MAU2 chromatid cohesion factor homolog isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC167132
      UniProtKB/Swiss-Prot
      B7ZN38, Q059Q4, Q5DU12, Q78IR4, Q8BUW9, Q8BX04, Q9D2X5
      Related
      ENSMUSP00000148601.2, ENSMUST00000212451.2
      Conserved Domains (2) summary
      sd00006
      Location:71100
      TPR; TPR repeat [structural motif]
      pfam10345
      Location:30576
      Cohesin_load; Cohesin loading factor
    3. NM_001376947.1NP_001363876.1  MAU2 chromatid cohesion factor homolog isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC167132
      Conserved Domains (2) summary
      sd00006
      Location:183211
      TPR; TPR repeat [structural motif]
      pfam10345
      Location:1374
      Cohesin_load; Cohesin loading factor
    4. NM_001376948.1NP_001363877.1  MAU2 chromatid cohesion factor homolog isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC167132
      Conserved Domains (2) summary
      sd00006
      Location:183211
      TPR; TPR repeat [structural motif]
      pfam10345
      Location:25373
      Cohesin_load; Cohesin loading factor
    5. NM_001376949.1NP_001363878.1  MAU2 chromatid cohesion factor homolog isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC167132
      Conserved Domains (2) summary
      sd00006
      Location:180208
      TPR; TPR repeat [structural motif]
      pfam10345
      Location:25370
      Cohesin_load; Cohesin loading factor
    6. NM_028993.5NP_083269.4  MAU2 chromatid cohesion factor homolog isoform 2

      See identical proteins and their annotated locations for NP_083269.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This difference results in a protein (isoform 2) that is one amino acid shorter than isoform 1.
      Source sequence(s)
      AC167132
      Consensus CDS
      CCDS40364.1
      Related
      ENSMUSP00000054763.7, ENSMUST00000050561.13
      Conserved Domains (2) summary
      sd00006
      Location:71100
      TPR; TPR repeat [structural motif]
      pfam10345
      Location:30575
      Cohesin_load; Cohesin loading factor

    RNA

    1. NR_165036.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC167132
    2. NR_165037.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC167132

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      70465896..70495384 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154341.1XP_036010234.1  MAU2 chromatid cohesion factor homolog isoform X2

      Conserved Domains (2) summary
      sd00006
      Location:71100
      TPR; TPR repeat [structural motif]
      pfam10345
      Location:30607
      Cohesin_load; Cohesin loading factor
    2. XM_036154340.1XP_036010233.1  MAU2 chromatid cohesion factor homolog isoform X1

      Conserved Domains (2) summary
      sd00006
      Location:71100
      TPR; TPR repeat [structural motif]
      pfam10345
      Location:30608
      Cohesin_load; Cohesin loading factor

    RNA

    1. XR_004934891.1 RNA Sequence

      Related
      ENSMUST00000212845.2