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    Tut7 terminal uridylyl transferase 7 [ Mus musculus (house mouse) ]

    Gene ID: 214290, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tut7provided by MGI
    Official Full Name
    terminal uridylyl transferase 7provided by MGI
    Primary source
    MGI:MGI:2387179
    See related
    Ensembl:ENSMUSG00000035248 AllianceGenome:MGI:2387179
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tent3b; Zcchc6; 6030448M23Rik
    Summary
    Enables uridylyltransferase activity. Involved in RNA 3' uridylation; oocyte maturation; and polyuridylation-dependent mRNA catabolic process. Predicted to be located in cytosol and nucleoplasm. Is expressed in several structures, including autopod; early conceptus; genitourinary system; sensory organ; and skeleton. Orthologous to human TUT7 (terminal uridylyl transferase 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 11.4), liver E14.5 (RPKM 9.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tut7 in Genome Data Viewer
    Location:
    13 B2; 13 31.88 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (59919690..59971060, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (59771876..59823169, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated 31 subfamily D, member 1E Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:59871197-59871469 Neighboring gene iron-sulfur cluster assembly 1 Neighboring gene ethanol decreased 2 Neighboring gene STARR-seq mESC enhancer starr_34725 Neighboring gene predicted gene, 19866 Neighboring gene STARR-seq mESC enhancer starr_34726 Neighboring gene STARR-seq mESC enhancer starr_34727 Neighboring gene predicted gene, 35143

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Terminal uridyltransferase 7 regulates TLR4-triggered inflammation by controlling Regnase-1 mRNA uridylation and degradation. Lin CC, et al. Nat Commun, 2021 Jun 29. PMID 34188032, Free PMC Article
    2. TUT4/7-mediated uridylation of a coronavirus subgenomic RNAs delays viral replication. Gupta A, et al. Commun Biol, 2023 Apr 21. PMID 37085578, Free PMC Article
    3. Genetic Inactivation of ZCCHC6 Suppresses Interleukin-6 Expression and Reduces the Severity of Experimental Osteoarthritis in Mice. Ansari MY, et al. Arthritis Rheumatol, 2019 Apr. PMID 30302948, Free PMC Article
    4. The RNA uridyltransferase Zcchc6 is expressed in macrophages and impacts innate immune responses. Kozlowski E, et al. PLoS One, 2017. PMID 28665939, Free PMC Article
    5. A programmed wave of uridylation-primed mRNA degradation is essential for meiotic progression and mammalian spermatogenesis. Morgan M, et al. Cell Res, 2019 Mar. PMID 30617251, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TUT4/7-mediated uridylation of a coronavirus subgenomic RNAs delays viral replication.
      Title: TUT4/7-mediated uridylation of a coronavirus subgenomic RNAs delays viral replication.
    2. Terminal uridyltransferase 7 regulates TLR4-triggered inflammation by controlling Regnase-1 mRNA uridylation and degradation.
      Title: Terminal uridyltransferase 7 regulates TLR4-triggered inflammation by controlling Regnase-1 mRNA uridylation and degradation.
    3. ZCCHC6 (TUT7) was markedly up-regulated in damaged cartilage from human osteoarthritis (OA) patients and from wild-type mice with surgically induced OA.
      Title: Genetic Inactivation of ZCCHC6 Suppresses Interleukin-6 Expression and Reduces the Severity of Experimental Osteoarthritis in Mice.
    4. Following an intratracheal challenge with S. pneumoniae, Zcchc6 deficiency led to a modest but significant increase in the expression of select cytokines including IL-6, CXCL1, and CXCL5. These findings were recapitulated in vitro whereby Zcchc6-deficient macrophages exhibited similar increases in cytokine expression due to bacterial stimulation
      Title: The RNA uridyltransferase Zcchc6 is expressed in macrophages and impacts innate immune responses.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC38585

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA uridylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA uridylyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA uridylyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables RNA uridylyltransferase activity TAS
    Traceable Author Statement
    more info
    		  
    enables miRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables miRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables uridylyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables uridylyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables uridylyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA 3' uridylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA 3' uridylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in RNA 3' uridylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in RNA 3' uridylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in RNA 3'-end processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in RNA 3'-end processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    NOT involved_in histone mRNA catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in miRNA metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in miRNA metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in oocyte maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in polyuridylation-dependent mRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pre-miRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pre-miRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in transposable element silencing by mRNA destabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transposable element silencing by mRNA destabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    terminal uridylyltransferase 7
    Names
    TUTase 7
    zinc finger CCHC domain-containing protein 6
    zinc finger, CCHC domain containing 6
    NP_001360891.1
    NP_001360892.1
    NP_001360893.1
    NP_705766.3
    XP_006517270.1
    XP_006517272.1
    XP_036013864.1
    XP_036013865.1
    XP_036013866.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001373962.1 → NP_001360891.1  terminal uridylyltransferase 7 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC125350, AC134869
      UniProtKB/Swiss-Prot
      A1A4B1, Q3V3V7, Q5BLK4, Q8CIH3
      Conserved Domains (6) summary
      smart00343
      Location:1448 → 1464
      ZnF_C2HC; zinc finger
      COG5260
      Location:975 → 1306
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
      TIGR00927
      Location:673 → 910
      2A1904; K+-dependent Na+/Ca+ exchanger
      pfam03828
      Location:550 → 599
      PAP_assoc; Cid1 family poly A polymerase
      pfam16631
      Location:1365 → 1446
      TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
      pfam19088
      Location:205 → 539
      TUTase; TUTase nucleotidyltransferase domain

    2. NM_001373963.1 → NP_001360892.1  terminal uridylyltransferase 7 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC125350, AC134869
      UniProtKB/Swiss-Prot
      A1A4B1, Q3V3V7, Q5BLK4, Q8CIH3
      Conserved Domains (6) summary
      smart00343
      Location:1448 → 1464
      ZnF_C2HC; zinc finger
      COG5260
      Location:975 → 1306
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
      TIGR00927
      Location:673 → 910
      2A1904; K+-dependent Na+/Ca+ exchanger
      pfam03828
      Location:550 → 599
      PAP_assoc; Cid1 family poly A polymerase
      pfam16631
      Location:1365 → 1446
      TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
      pfam19088
      Location:205 → 539
      TUTase; TUTase nucleotidyltransferase domain

    3. NM_001373964.1 → NP_001360893.1  terminal uridylyltransferase 7 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125350, AC134869
      Conserved Domains (6) summary
      smart00343
      Location:1448 → 1464
      ZnF_C2HC; zinc finger
      COG5260
      Location:975 → 1306
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
      TIGR00927
      Location:673 → 910
      2A1904; K+-dependent Na+/Ca+ exchanger
      pfam03828
      Location:550 → 599
      PAP_assoc; Cid1 family poly A polymerase
      pfam16631
      Location:1365 → 1446
      TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
      pfam19088
      Location:205 → 539
      TUTase; TUTase nucleotidyltransferase domain

    4. NM_153538.3 → NP_705766.3  terminal uridylyltransferase 7 isoform 2

      See identical proteins and their annotated locations for NP_705766.3

      Status: VALIDATED

      Source sequence(s)
      BC043111, CB526652, CJ054882
      Consensus CDS
      CCDS36689.1
      UniProtKB/TrEMBL
      E9PUA2
      Related
      ENSMUSP00000071623.5, ENSMUST00000071703.6
      Conserved Domains (6) summary
      smart00343
      Location:1448 → 1464
      ZnF_C2HC; zinc finger
      COG5260
      Location:975 → 1306
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
      TIGR00927
      Location:673 → 910
      2A1904; K+-dependent Na+/Ca+ exchanger
      pfam03828
      Location:550 → 599
      PAP_assoc; Cid1 family poly A polymerase
      pfam16631
      Location:1365 → 1446
      TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
      pfam19088
      Location:205 → 539
      TUTase; TUTase nucleotidyltransferase domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      59919690..59971060 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157972.1 → XP_036013865.1  terminal uridylyltransferase 7 isoform X2

      UniProtKB/Swiss-Prot
      A1A4B1, Q3V3V7, Q5BLK4, Q8CIH3
      Conserved Domains (6) summary
      smart00343
      Location:1448 → 1464
      ZnF_C2HC; zinc finger
      COG5260
      Location:975 → 1306
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
      TIGR00927
      Location:673 → 910
      2A1904; K+-dependent Na+/Ca+ exchanger
      pfam03828
      Location:550 → 599
      PAP_assoc; Cid1 family poly A polymerase
      pfam16631
      Location:1365 → 1446
      TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
      pfam19088
      Location:205 → 539
      TUTase; TUTase nucleotidyltransferase domain

    2. XM_036157971.1 → XP_036013864.1  terminal uridylyltransferase 7 isoform X1

      Conserved Domains (6) summary
      smart00343
      Location:1448 → 1464
      ZnF_C2HC; zinc finger
      COG5260
      Location:975 → 1306
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
      TIGR00927
      Location:673 → 910
      2A1904; K+-dependent Na+/Ca+ exchanger
      pfam03828
      Location:550 → 599
      PAP_assoc; Cid1 family poly A polymerase
      pfam16631
      Location:1365 → 1446
      TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
      pfam19088
      Location:205 → 539
      TUTase; TUTase nucleotidyltransferase domain

    3. XM_006517209.3 → XP_006517272.1  terminal uridylyltransferase 7 isoform X3

      See identical proteins and their annotated locations for XP_006517272.1

      UniProtKB/TrEMBL
      E9PUA2
      Conserved Domains (6) summary
      smart00343
      Location:1448 → 1464
      ZnF_C2HC; zinc finger
      COG5260
      Location:975 → 1306
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
      TIGR00927
      Location:673 → 910
      2A1904; K+-dependent Na+/Ca+ exchanger
      pfam03828
      Location:550 → 599
      PAP_assoc; Cid1 family poly A polymerase
      pfam16631
      Location:1365 → 1446
      TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
      pfam19088
      Location:205 → 539
      TUTase; TUTase nucleotidyltransferase domain

    4. XM_006517207.3 → XP_006517270.1  terminal uridylyltransferase 7 isoform X1

      See identical proteins and their annotated locations for XP_006517270.1

      Conserved Domains (6) summary
      smart00343
      Location:1448 → 1464
      ZnF_C2HC; zinc finger
      COG5260
      Location:975 → 1306
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
      TIGR00927
      Location:673 → 910
      2A1904; K+-dependent Na+/Ca+ exchanger
      pfam03828
      Location:550 → 599
      PAP_assoc; Cid1 family poly A polymerase
      pfam16631
      Location:1365 → 1446
      TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
      pfam19088
      Location:205 → 539
      TUTase; TUTase nucleotidyltransferase domain

    5. XM_036157973.1 → XP_036013866.1  terminal uridylyltransferase 7 isoform X3

      UniProtKB/TrEMBL
      E9PUA2
      Conserved Domains (6) summary
      smart00343
      Location:1448 → 1464
      ZnF_C2HC; zinc finger
      COG5260
      Location:975 → 1306
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
      TIGR00927
      Location:673 → 910
      2A1904; K+-dependent Na+/Ca+ exchanger
      pfam03828
      Location:550 → 599
      PAP_assoc; Cid1 family poly A polymerase
      pfam16631
      Location:1365 → 1446
      TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
      pfam19088
      Location:205 → 539
      TUTase; TUTase nucleotidyltransferase domain

    RNA

    1. XR_003950443.2 RNA Sequence

    2. XR_004938011.1 RNA Sequence

    3. XR_004938012.1 RNA Sequence

    4. XR_003950441.2 RNA Sequence

    5. XR_003950442.1 RNA Sequence

    6. XR_004938010.1 RNA Sequence

      Related
      ENSMUST00000224480.2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5BLK4.3 GenPept UniProtKB/Swiss-Prot:Q5BLK4

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