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    Gnb3 guanine nucleotide binding protein (G protein), beta 3 [ Mus musculus (house mouse) ]

    Gene ID: 14695, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gnb3provided by MGI
    Official Full Name
    guanine nucleotide binding protein (G protein), beta 3provided by MGI
    Primary source
    MGI:MGI:95785
    See related
    Ensembl:ENSMUSG00000023439 AllianceGenome:MGI:95785
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hg2d; Gnb-3
    Summary
    Predicted to enable GTPase binding activity; signaling receptor complex adaptor activity; and spectrin binding activity. Predicted to be involved in several processes, including cell volume homeostasis; regulation of fat cell differentiation; and regulation of lipid metabolic process. Located in dendrite. Part of heterotrimeric G-protein complex. Is expressed in several structures, including brain; eye; ganglia; gut; and spleen. Human ortholog(s) of this gene implicated in artery disease (multiple); congenital stationary night blindness 1H; depressive disorder; familial hyperlipidemia; and type 2 diabetes mellitus. Orthologous to human GNB3 (G protein subunit beta 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in adrenal adult (RPKM 3.8), heart adult (RPKM 3.5) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Gnb3 in Genome Data Viewer
    Location:
    6 F2; 6 59.17 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (124811203..124817238, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (124834240..124840275, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 5 (isopeptidase T) Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:124778211-124778394 Neighboring gene cell division cycle associated 3 Neighboring gene prolyl 3-hydroxylase 3 Neighboring gene STARR-positive B cell enhancer ABC_E6487 Neighboring gene predicted gene, 32404 Neighboring gene G protein-coupled receptor 162

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor complex adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables spectrin binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cell volume homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell volume homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cholesterol metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cholesterol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of glucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of glucose metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of hormone metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of hormone metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of phospholipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of phospholipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of triglyceride metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of triglyceride metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of heterotrimeric G-protein complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of heterotrimeric G-protein complex TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
    Names
    heterotrimeric guanine nucleotide-binding protein 2d
    transducin beta chain 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013530.1NP_038558.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3

      See identical proteins and their annotated locations for NP_038558.1

      Status: VALIDATED

      Source sequence(s)
      BC018239
      Consensus CDS
      CCDS20532.1
      UniProtKB/Swiss-Prot
      Q61011
      UniProtKB/TrEMBL
      Q54AE3, Q8BMQ1
      Related
      ENSMUSP00000024206.6, ENSMUST00000024206.6
      Conserved Domains (2) summary
      cd00200
      Location:48340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:5895
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      124811203..124817238 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)