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    Vstm4 V-set and transmembrane domain containing 4 [ Mus musculus (house mouse) ]

    Gene ID: 320736, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Vstm4provided by MGI
    Official Full Name
    V-set and transmembrane domain containing 4provided by MGI
    Primary source
    MGI:MGI:2444633
    See related
    Ensembl:ENSMUSG00000050666 AllianceGenome:MGI:2444633
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E130203B14Rik
    Summary
    Acts upstream of or within several processes, including endothelial cell proliferation; retina blood vessel maintenance; and vasculature development. Predicted to be located in extracellular region and plasma membrane. Predicted to be active in membrane. Orthologous to human VSTM4 (V-set and transmembrane domain containing 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in placenta adult (RPKM 15.0), bladder adult (RPKM 6.8) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Vstm4 in Genome Data Viewer
    Location:
    14 B; 14 19.4 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (32578713..32661448)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (32856756..32939491)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 273 Neighboring gene family with sequence similarity 170, member B Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 36674 Neighboring gene WD repeat and FYVE domain containing 4 Neighboring gene leucine rich repeat containing 18 Neighboring gene STARR-positive B cell enhancer ABC_E4104 Neighboring gene STARR-positive B cell enhancer ABC_E1893 Neighboring gene predicted gene, 25498

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Newly Identified Peptide, Peptide Lv, Promotes Pathological Angiogenesis. Shi L, et al. J Am Heart Assoc, 2019 Nov 19. PMID 31698979, Free PMC Article
    2. Peptide Lv augments L-type voltage-gated calcium channels through vascular endothelial growth factor receptor 2 (VEGFR2) signaling. Shi L, et al. Biochim Biophys Acta, 2015 May. PMID 25698653, Free PMC Article
    3. Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion. Gu Z, et al. PLoS One, 2015. PMID 25826454, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Vascular endothelial growth factor receptor 2 (VEGFR2) interacted with peptide Lv.
      Title: Peptide Lv augments L-type voltage-gated calcium channels through vascular endothelial growth factor receptor 2 (VEGFR2) signaling.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within endothelial cell migration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within endothelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within retina blood vessel maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within retina vasculature development in camera-type eye IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within sprouting angiogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within vasodilation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within vasodilation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    V-set and transmembrane domain-containing protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001361602.1 → NP_001348531.1  V-set and transmembrane domain-containing protein 4 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC133585

    2. NM_178791.5 → NP_848906.1  V-set and transmembrane domain-containing protein 4 isoform 1 precursor

      See identical proteins and their annotated locations for NP_848906.1

      Status: VALIDATED

      Source sequence(s)
      AC133585
      Consensus CDS
      CCDS26923.1
      UniProtKB/Swiss-Prot
      T1NXB5
      Related
      ENSMUSP00000055178.6, ENSMUST00000053175.13

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      32578713..32661448
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    T1NXB5.1 GenPept UniProtKB/Swiss-Prot:T1NXB5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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