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    Gse1 genetic suppressor element 1, coiled-coil protein [ Mus musculus (house mouse) ]

    Gene ID: 382034, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gse1provided by MGI
    Official Full Name
    genetic suppressor element 1, coiled-coil proteinprovided by MGI
    Primary source
    MGI:MGI:1098275
    See related
    Ensembl:ENSMUSG00000031822 AllianceGenome:MGI:1098275
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0182; 2210013I18Rik
    Summary
    Is expressed in cerebral cortex subventricular zone and cortical plate. Human ortholog(s) of this gene implicated in stomach cancer. Orthologous to human GSE1 (Gse1 coiled-coil protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 46.5), colon adult (RPKM 18.1) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gse1 in Genome Data Viewer
    Location:
    8 E1; 8 69.69 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (120955233..121308122)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (120228501..120581383)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr8:122701278-122701579 Neighboring gene STARR-positive B cell enhancer ABC_E5046 Neighboring gene RIKEN cDNA A330074K22 gene Neighboring gene CBY1 interacting BAR domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E10527 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:122809115-122809356 Neighboring gene VISTA enhancer mm196 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:122831174-122831375 Neighboring gene STARR-seq mESC enhancer starr_22881 Neighboring gene STARR-seq mESC enhancer starr_22882 Neighboring gene VISTA enhancer mm1642 Neighboring gene predicted gene, 32968 Neighboring gene VISTA enhancer mm99 Neighboring gene predicted gene, 39264 Neighboring gene STARR-seq mESC enhancer starr_22885 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:122936895-122937096 Neighboring gene VISTA enhancer mm1674 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:122997596-122997871 Neighboring gene STARR-positive B cell enhancer ABC_E1773 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:123021612-123021863 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:123037840-123038041 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:123038181-123038364 Neighboring gene predicted gene, 51556 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:123052195-123052396 Neighboring gene RIKEN cDNA 1700016A09 gene Neighboring gene STARR-positive B cell enhancer ABC_E9746 Neighboring gene STARR-positive B cell enhancer ABC_E362 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:123063389-123063498 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:123067513-123067836 Neighboring gene microRNA 7687 Neighboring gene STARR-positive B cell enhancer ABC_E246 Neighboring gene RIKEN cDNA 1190005I06 gene Neighboring gene predicted gene 10614 Neighboring gene GINS complex subunit 2 Neighboring gene STARR-seq mESC enhancer starr_22909 Neighboring gene predicted gene, 27021 Neighboring gene predicted gene, 33075

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Temporal change in mKIAA gene expression during the early stage of retinoic acid-induced neurite outgrowth. Imai K, et al. Gene, 2005 Dec 30. PMID 16169686
    2. Cloning mammalian genes by expression selection of genetic suppressor elements: association of kinesin with drug resistance and cell immortalization. Gudkov AV, et al. Proc Natl Acad Sci U S A, 1994 Apr 26. PMID 8170981, Free PMC Article
    3. Gse1, a component of the CoREST complex, is required for placenta development in the mouse. Hiver S, et al. Dev Biol, 2023 Jun. PMID 37019373
    4. Aberrant differentiation of second heart field mesoderm prefigures cellular defects in the outflow tract in response to loss of FGF8. Astrof S, et al. Dev Biol, 2023 Jul. PMID 37060937, Free PMC Article
    5. Corticothalamic Projection Neuron Development beyond Subtype Specification: Fog2 and Intersectional Controls Regulate Intraclass Neuronal Diversity. Galazo MJ, et al. Neuron, 2016 Jul 6. PMID 27321927, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gse1, a component of the CoREST complex, is required for placenta development in the mouse.
      Title: Gse1, a component of the CoREST complex, is required for placenta development in the mouse.
    2. Some mKIAA genes are apparently relevant to retinoic acid-induced neurite outgrowth. (mKIAA gene)
      Title: Temporal change in mKIAA gene expression during the early stage of retinoic acid-induced neurite outgrowth.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC58013

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    genetic suppressor element 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145896.1 → NP_001139368.1  genetic suppressor element 1 isoform 2

      See identical proteins and their annotated locations for NP_001139368.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and contains an alternate 5' coding region, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AI854638, AK042915, BC043094, BY766823
      Consensus CDS
      CCDS52688.1
      UniProtKB/Swiss-Prot
      Q3U3C9, Q3UWZ5, Q80U67, Q80XR0, Q8CCF2
      Related
      ENSMUSP00000112981.2, ENSMUST00000118136.2
      Conserved Domains (2) summary
      pfam12540
      Location:732 → 872
      DUF3736; Protein of unknown function (DUF3736)
      pfam16716
      Location:1138 → 1196
      BST2; Bone marrow stromal antigen 2

    2. NM_001145897.1 → NP_001139369.1  genetic suppressor element 1 isoform 3

      See identical proteins and their annotated locations for NP_001139369.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream translational start codon, compared to variant 1. The encoded isoform (3) is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AI854638, AK033263, BB624394, BC043094
      Consensus CDS
      CCDS52689.1
      UniProtKB/Swiss-Prot
      Q3U3C9
      Related
      ENSMUSP00000113577.2, ENSMUST00000120493.8
      Conserved Domains (1) summary
      pfam12540
      Location:729 → 869
      DUF3736; Protein of unknown function (DUF3736)

    3. NM_198671.2 → NP_941073.2  genetic suppressor element 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AI854638, BC043094
      Consensus CDS
      CCDS52687.1
      UniProtKB/Swiss-Prot
      Q3U3C9
      Related
      ENSMUSP00000034279.9, ENSMUST00000034279.16
      Conserved Domains (1) summary
      pfam12540
      Location:742 → 883
      DUF3736; Protein of unknown function (DUF3736)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      120955233..121308122
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531145.5 → XP_006531208.3  genetic suppressor element 1 isoform X1

      Conserved Domains (2) summary
      pfam12540
      Location:1442 → 1582
      DUF3736; Protein of unknown function (DUF3736)
      pfam16716
      Location:1848 → 1906
      BST2; Bone marrow stromal antigen 2

    2. XM_006531146.5 → XP_006531209.3  genetic suppressor element 1 isoform X2

      Conserved Domains (2) summary
      pfam12540
      Location:1442 → 1582
      DUF3736; Protein of unknown function (DUF3736)
      pfam16716
      Location:1812 → 1870
      BST2; Bone marrow stromal antigen 2

    3. XM_006531147.4 → XP_006531210.3  genetic suppressor element 1 isoform X3

      Conserved Domains (3) summary
      PHA03247
      Location:633 → 965
      PHA03247; large tegument protein UL36; Provisional
      pfam12540
      Location:1369 → 1509
      DUF3736; Protein of unknown function (DUF3736)
      pfam16716
      Location:1775 → 1833
      BST2; Bone marrow stromal antigen 2

    4. XM_030243649.2 → XP_030099509.1  genetic suppressor element 1 isoform X5

      Conserved Domains (2) summary
      pfam12540
      Location:742 → 882
      DUF3736; Protein of unknown function (DUF3736)
      pfam16716
      Location:1112 → 1170
      BST2; Bone marrow stromal antigen 2

    5. XM_036154145.1 → XP_036010038.1  genetic suppressor element 1 isoform X8

      Conserved Domains (1) summary
      pfam12540
      Location:669 → 809
      DUF3736; Protein of unknown function (DUF3736)

    6. XM_006531148.5 → XP_006531211.1  genetic suppressor element 1 isoform X6

      Conserved Domains (2) summary
      pfam12540
      Location:669 → 809
      DUF3736; Protein of unknown function (DUF3736)
      pfam16716
      Location:1075 → 1133
      BST2; Bone marrow stromal antigen 2

    7. XM_036154143.1 → XP_036010036.1  genetic suppressor element 1 isoform X4

      Conserved Domains (1) summary
      pfam12540
      Location:729 → 869
      DUF3736; Protein of unknown function (DUF3736)

    8. XM_030243648.1 → XP_030099508.1  genetic suppressor element 1 isoform X4

      Conserved Domains (1) summary
      pfam12540
      Location:729 → 869
      DUF3736; Protein of unknown function (DUF3736)

    9. XM_036154144.1 → XP_036010037.1  genetic suppressor element 1 isoform X4

      Conserved Domains (1) summary
      pfam12540
      Location:729 → 869
      DUF3736; Protein of unknown function (DUF3736)

    10. XM_030243647.1 → XP_030099507.1  genetic suppressor element 1 isoform X4

      Conserved Domains (1) summary
      pfam12540
      Location:729 → 869
      DUF3736; Protein of unknown function (DUF3736)

    11. XM_006531149.5 → XP_006531212.1  genetic suppressor element 1 isoform X7

      Conserved Domains (2) summary
      pfam12540
      Location:659 → 799
      DUF3736; Protein of unknown function (DUF3736)
      pfam16716
      Location:1065 → 1123
      BST2; Bone marrow stromal antigen 2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3U3C9.2 GenPept UniProtKB/Swiss-Prot:Q3U3C9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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