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    Cant1 calcium activated nucleotidase 1 [ Mus musculus (house mouse) ]

    Gene ID: 76025, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cant1provided by MGI
    Official Full Name
    calcium activated nucleotidase 1provided by MGI
    Primary source
    MGI:MGI:1923275
    See related
    Ensembl:ENSMUSG00000025575 AllianceGenome:MGI:1923275
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Apy1h; Shapy; Entpd8; SCAN-1; D11Bwg0554e; 5830420C20Rik
    Summary
    The protein encoded by this gene is a calcium-dependent nucleotidase that preferentially hydrolyzes UDP, GDP, and IDP. The encoded protein has low activity with ADP and ATP and shows no activity with AMP and GMP. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]
    Expression
    Ubiquitous expression in colon adult (RPKM 53.2), duodenum adult (RPKM 33.4) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Cant1 in Genome Data Viewer
    Location:
    11 E2; 11 83.15 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (118297115..118309971, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (118406289..118419134, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene tissue inhibitor of metalloproteinase 2 Neighboring gene CEP295 N-terminal like Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:118209837-118210038 Neighboring gene lectin, galactoside-binding, soluble, 3 binding protein Neighboring gene STARR-seq mESC enhancer starr_31301 Neighboring gene STARR-positive B cell enhancer ABC_E5311 Neighboring gene predicted gene, 35598 Neighboring gene C1q and tumor necrosis factor related protein 1 Neighboring gene predicted gene 11747

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ADP phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ADP phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables GDP phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GDP phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables UDP phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables UDP phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in proteoglycan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteoglycan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteoglycan biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within ribonucleoside diphosphate catabolic process IC
    Inferred by Curator
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    soluble calcium-activated nucleotidase 1
    Names
    Ca2+-dependent endoplasmic reticulum nucleoside diphosphatase
    apyrase 1, homolog (C. lectularius)
    apyrase homolog
    NP_001020788.1
    NP_001020789.1
    NP_001254520.1
    NP_001254521.1
    NP_083778.2
    XP_006534467.1
    XP_006534468.1
    XP_006534469.1
    XP_006534470.1
    XP_006534471.1
    XP_006534472.1
    XP_006534473.1
    XP_030102267.1
    XP_030102268.1
    XP_030102269.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025617.2NP_001020788.1  soluble calcium-activated nucleotidase 1 isoform a

      See identical proteins and their annotated locations for NP_001020788.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 all encode the same isoform (a).
      Source sequence(s)
      AK081118, AL591075, AL591404, BF465199, CD562087
      Consensus CDS
      CCDS25702.1
      UniProtKB/Swiss-Prot
      B1AQJ8, Q8C3R8, Q8C4T6, Q8VCF1, Q9D3F2, Q9D9R1
      Related
      ENSMUSP00000101895.2, ENSMUST00000106288.8
      Conserved Domains (1) summary
      pfam06079
      Location:115402
      Apyrase
    2. NM_001025618.2NP_001020789.1  soluble calcium-activated nucleotidase 1 isoform a

      See identical proteins and their annotated locations for NP_001020789.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 all encode the same isoform (a).
      Source sequence(s)
      AK049879, AL591075, AL591404, BF465199
      Consensus CDS
      CCDS25702.1
      UniProtKB/Swiss-Prot
      B1AQJ8, Q8C3R8, Q8C4T6, Q8VCF1, Q9D3F2, Q9D9R1
      Related
      ENSMUSP00000101894.2, ENSMUST00000106287.8
      Conserved Domains (1) summary
      pfam06079
      Location:115402
      Apyrase
    3. NM_001267591.1NP_001254520.1  soluble calcium-activated nucleotidase 1 isoform a

      See identical proteins and their annotated locations for NP_001254520.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 all encode the same isoform (a).
      Source sequence(s)
      AK049879, AL591404, BF465199
      Consensus CDS
      CCDS25702.1
      UniProtKB/Swiss-Prot
      B1AQJ8, Q8C3R8, Q8C4T6, Q8VCF1, Q9D3F2, Q9D9R1
      Related
      ENSMUSP00000126919.2, ENSMUST00000164927.2
      Conserved Domains (1) summary
      pfam06079
      Location:115402
      Apyrase
    4. NM_001267592.1NP_001254521.1  soluble calcium-activated nucleotidase 1 isoform b

      See identical proteins and their annotated locations for NP_001254521.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and contains an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is longer compared to isoform a.
      Source sequence(s)
      AK006565, AL591075, AL591404, BF465199
      Consensus CDS
      CCDS59572.1
      UniProtKB/Swiss-Prot
      Q8VCF1
      Related
      ENSMUSP00000101896.3, ENSMUST00000106289.9
      Conserved Domains (1) summary
      pfam06079
      Location:115439
      Apyrase
    5. NM_029502.3NP_083778.2  soluble calcium-activated nucleotidase 1 isoform a

      See identical proteins and their annotated locations for NP_083778.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a. Variants 1, 2, 3, and 4 all encode the same isoform (a).
      Source sequence(s)
      AK049879, AK081118, AL591075, AL591404, BF465199
      Consensus CDS
      CCDS25702.1
      UniProtKB/Swiss-Prot
      B1AQJ8, Q8C3R8, Q8C4T6, Q8VCF1, Q9D3F2, Q9D9R1
      Related
      ENSMUSP00000090032.4, ENSMUST00000092378.10
      Conserved Domains (1) summary
      pfam06079
      Location:115402
      Apyrase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      118297115..118309971 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534409.2XP_006534472.1  soluble calcium-activated nucleotidase 1 isoform X1

      See identical proteins and their annotated locations for XP_006534472.1

      UniProtKB/Swiss-Prot
      Q8VCF1
      Conserved Domains (1) summary
      pfam06079
      Location:115439
      Apyrase
    2. XM_030246409.2XP_030102269.1  soluble calcium-activated nucleotidase 1 isoform X2

      UniProtKB/Swiss-Prot
      B1AQJ8, Q8C3R8, Q8C4T6, Q8VCF1, Q9D3F2, Q9D9R1
      Conserved Domains (1) summary
      pfam06079
      Location:115402
      Apyrase
    3. XM_006534407.4XP_006534470.1  soluble calcium-activated nucleotidase 1 isoform X1

      See identical proteins and their annotated locations for XP_006534470.1

      UniProtKB/Swiss-Prot
      Q8VCF1
      Conserved Domains (1) summary
      pfam06079
      Location:115439
      Apyrase
    4. XM_030246408.2XP_030102268.1  soluble calcium-activated nucleotidase 1 isoform X2

      UniProtKB/Swiss-Prot
      B1AQJ8, Q8C3R8, Q8C4T6, Q8VCF1, Q9D3F2, Q9D9R1
      Conserved Domains (1) summary
      pfam06079
      Location:115402
      Apyrase
    5. XM_006534406.4XP_006534469.1  soluble calcium-activated nucleotidase 1 isoform X1

      See identical proteins and their annotated locations for XP_006534469.1

      UniProtKB/Swiss-Prot
      Q8VCF1
      Conserved Domains (1) summary
      pfam06079
      Location:115439
      Apyrase
    6. XM_030246407.2XP_030102267.1  soluble calcium-activated nucleotidase 1 isoform X2

      UniProtKB/Swiss-Prot
      B1AQJ8, Q8C3R8, Q8C4T6, Q8VCF1, Q9D3F2, Q9D9R1
      Conserved Domains (1) summary
      pfam06079
      Location:115402
      Apyrase
    7. XM_006534405.4XP_006534468.1  soluble calcium-activated nucleotidase 1 isoform X1

      See identical proteins and their annotated locations for XP_006534468.1

      UniProtKB/Swiss-Prot
      Q8VCF1
      Conserved Domains (1) summary
      pfam06079
      Location:115439
      Apyrase
    8. XM_006534404.4XP_006534467.1  soluble calcium-activated nucleotidase 1 isoform X1

      See identical proteins and their annotated locations for XP_006534467.1

      UniProtKB/Swiss-Prot
      Q8VCF1
      Conserved Domains (1) summary
      pfam06079
      Location:115439
      Apyrase
    9. XM_006534410.5XP_006534473.1  soluble calcium-activated nucleotidase 1 isoform X1

      See identical proteins and their annotated locations for XP_006534473.1

      UniProtKB/Swiss-Prot
      Q8VCF1
      Conserved Domains (1) summary
      pfam06079
      Location:115439
      Apyrase
    10. XM_006534408.5XP_006534471.1  soluble calcium-activated nucleotidase 1 isoform X1

      See identical proteins and their annotated locations for XP_006534471.1

      UniProtKB/Swiss-Prot
      Q8VCF1
      Conserved Domains (1) summary
      pfam06079
      Location:115439
      Apyrase