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    Krt15 keratin 15 [ Mus musculus (house mouse) ]

    Gene ID: 16665, updated on 9-Dec-2024

    Summary

    Official Symbol
    Krt15provided by MGI
    Official Full Name
    keratin 15provided by MGI
    Primary source
    MGI:MGI:96689
    See related
    Ensembl:ENSMUSG00000054146 AllianceGenome:MGI:96689
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    K15; Krt1-15
    Summary
    Predicted to enable scaffold protein binding activity. Predicted to be involved in epithelial cell differentiation and intermediate filament organization. Predicted to be located in intermediate filament. Predicted to be active in cytoskeleton. Is expressed in several structures, including alimentary system; genitourinary system; respiratory system; sensory organ; and skin. Orthologous to human KRT15 (keratin 15). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in bladder adult (RPKM 231.5), limb E14.5 (RPKM 52.7) and 1 other tissue See more
    Orthologs
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    Genomic context

    See Krt15 in Genome Data Viewer
    Location:
    11 D; 11 63.41 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (100022585..100026775, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (100131759..100135949, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene keratin 36 Neighboring gene keratin 13 Neighboring gene keratin 19 Neighboring gene predicted gene, 39022

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4)  1 citation
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables scaffold protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in epithelial cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intermediate filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in intermediate filament IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    keratin, type I cytoskeletal 15
    Names
    CK-15
    cytokeratin-15
    keratin complex 1, acidic, gene 15

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008469.2NP_032495.2  keratin, type I cytoskeletal 15

      See identical proteins and their annotated locations for NP_032495.2

      Status: VALIDATED

      Source sequence(s)
      BY061070, BY107287, BY436080, CA451823, CN456368
      Consensus CDS
      CCDS25410.2
      UniProtKB/TrEMBL
      B1AQ77
      Related
      ENSMUSP00000103034.3, ENSMUST00000107411.3
      Conserved Domains (1) summary
      pfam00038
      Location:97409
      Filament; Intermediate filament protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      100022585..100026775 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)