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    Krt20 keratin 20 [ Mus musculus (house mouse) ]

    Gene ID: 66809, updated on 9-Dec-2024

    Summary

    Official Symbol
    Krt20provided by MGI
    Official Full Name
    keratin 20provided by MGI
    Primary source
    MGI:MGI:1914059
    See related
    Ensembl:ENSMUSG00000035775 AllianceGenome:MGI:1914059
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    K20; Ck20; Ck-20; Krt21; 9030623C06Rik
    Summary
    This gene encodes a member of the keratin protein family and is found within a cluster of cytokeratin genes on chromosome 11. Keratins are cytoskeletal proteins that are preferentially expressed in epithelial cells. The encoded protein may help maintain intermediate filament organization in intestinal epithelium. Phosphorylation of this protein may also influence mucin secretion in the small intestine. [provided by RefSeq, Dec 2015]
    Expression
    Biased expression in large intestine adult (RPKM 276.4), small intestine adult (RPKM 251.1) and 5 other tissues See more
    Orthologs
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    Genomic context

    See Krt20 in Genome Data Viewer
    Location:
    11 D; 11 62.92 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (99319211..99328979, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (99428385..99438153, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr11:99247019-99247320 Neighboring gene STARR-positive B cell enhancer mm9_chr11:99247331-99247631 Neighboring gene keratin 10 Neighboring gene RIKEN cDNA A830036E02 gene Neighboring gene keratin 12 Neighboring gene keratin 23 Neighboring gene keratin 39

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to starvation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in epithelial cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intermediate filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intermediate filament organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intermediate filament organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intermediate filament IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intermediate filament cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    keratin, type I cytoskeletal 20
    Names
    cytokeratin 20

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023256.2NP_075745.1  keratin, type I cytoskeletal 20

      See identical proteins and their annotated locations for NP_075745.1

      Status: REVIEWED

      Source sequence(s)
      AK018567, AL591165
      Consensus CDS
      CCDS25381.1
      UniProtKB/Swiss-Prot
      Q6PG82, Q9D312
      Related
      ENSMUSP00000017743.3, ENSMUST00000017743.3
      Conserved Domains (1) summary
      pfam00038
      Location:76385
      Filament; Intermediate filament protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      99319211..99328979 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)