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    Nat2 N-acetyltransferase 2 (arylamine N-acetyltransferase) [ Mus musculus (house mouse) ]

    Gene ID: 17961, updated on 27-Nov-2024

    Summary

    Official Symbol
    Nat2provided by MGI
    Official Full Name
    N-acetyltransferase 2 (arylamine N-acetyltransferase)provided by MGI
    Primary source
    MGI:MGI:109201
    See related
    Ensembl:ENSMUSG00000051147 AllianceGenome:MGI:109201
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables arylamine N-acetyltransferase activity. Predicted to be located in cytoplasm. Is expressed in several structures, including adrenal gland; female reproductive system; respiratory system; spleen; and sympathetic ganglion. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); contact dermatitis (multiple); leukemia (multiple); and lung disease (multiple). Orthologous to several human genes including NAT1 (N-acetyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Annotation information
    Note: Loci in other organisms that are functionally homologous to this one are validly referred to as both NAT1 and NAT2; i.e., the functional homologs of NAT1 include mouse and rat Nat2, while the functional homologs of human NAT2 include mouse and rat Nat1. Name:sequence associations are consistent with current use in the field. [13 Feb 2013]
    Expression
    Broad expression in liver E14 (RPKM 1.2), liver E14.5 (RPKM 0.9) and 24 other tissues See more
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    Genomic context

    See Nat2 in Genome Data Viewer
    Location:
    8 B3.2; 8 33.38 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (67947527..67955296)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (67494875..67502644)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24677 Neighboring gene STARR-seq mESC enhancer starr_21692 Neighboring gene STARR-positive B cell enhancer mm9_chr8:69955113-69955414 Neighboring gene STARR-seq mESC enhancer starr_21694 Neighboring gene STARR-seq mESC enhancer starr_21695 Neighboring gene N-acetyl transferase 1 Neighboring gene Tu translation elongation factor pseudogene Neighboring gene N-acetyltransferase 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables N-hydroxyarylamine O-acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables N-hydroxyarylamine O-acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables arylamine N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables arylamine N-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables arylamine N-acetyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables arylamine N-acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    arylamine N-acetyltransferase 2
    Names
    N-acetyl transferase 2
    N-acetyltransferase type 2
    N-hydroxyarylamine O-acetyltransferase
    NAT-2
    arylamide acetylase 2
    NP_001162049.1
    NP_035004.1
    XP_006509655.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168577.1NP_001162049.1  arylamine N-acetyltransferase 2

      See identical proteins and their annotated locations for NP_001162049.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC122867, AK007583
      Consensus CDS
      CCDS22338.1
      UniProtKB/Swiss-Prot
      P50295
      UniProtKB/TrEMBL
      Q711M4, Q78ZC4, Q921E5
      Related
      ENSMUSP00000091181.6, ENSMUST00000093470.7
      Conserved Domains (1) summary
      pfam00797
      Location:20280
      Acetyltransf_2; N-acetyltransferase
    2. NM_010874.3NP_035004.1  arylamine N-acetyltransferase 2

      See identical proteins and their annotated locations for NP_035004.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC122867, AK007583
      Consensus CDS
      CCDS22338.1
      UniProtKB/Swiss-Prot
      P50295
      UniProtKB/TrEMBL
      Q711M4, Q78ZC4, Q921E5
      Related
      ENSMUSP00000130065.2, ENSMUST00000163856.3
      Conserved Domains (1) summary
      pfam00797
      Location:20280
      Acetyltransf_2; N-acetyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      67947527..67955296
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509592.2XP_006509655.1  arylamine N-acetyltransferase 2 isoform X1

      See identical proteins and their annotated locations for XP_006509655.1

      UniProtKB/TrEMBL
      Q921E5
      Conserved Domains (1) summary
      pfam00797
      Location:60320
      Acetyltransf_2; N-acetyltransferase