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    eif2b1 eukaryotic translation initiation factor 2B, subunit 1 alpha [ Danio rerio (zebrafish) ]

    Gene ID: 415150, updated on 4-Jan-2025

    Summary

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    Official Symbol
    eif2b1provided by ZNC
    Official Full Name
    eukaryotic translation initiation factor 2B, subunit 1 alphaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040625-25
    See related
    Ensembl:ENSDARG00000091402 AllianceGenome:ZFIN:ZDB-GENE-040625-25
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:86660
    Summary
    Predicted to contribute to guanyl-nucleotide exchange factor activity and translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to act upstream of or within translation. Predicted to be located in cytosol. Predicted to be part of eukaryotic translation initiation factor 2B complex. Is expressed in brain and eye. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter 1. Orthologous to human EIF2B1 (eukaryotic translation initiation factor 2B subunit alpha). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See eif2b1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (69641166..69649035, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (68868614..68876492, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene aldehyde dehydrogenase 2 family member, tandem duplicate 2 Neighboring gene VPS33A core subunit of CORVET and HOPS complexes Neighboring gene general transcription factor IIH, polypeptide 3 Neighboring gene zinc finger protein 154

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Vanishing white matter disease expression of truncated EIF2B5 activates induced stress response. Keefe MD, et al. Elife, 2020 Dec 10. PMID 33300869, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    contributes_to guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic translation initiation factor 2B complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    translation initiation factor eIF2B subunit alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002060.1 → NP_001002060.1  translation initiation factor eIF2B subunit alpha

      See identical proteins and their annotated locations for NP_001002060.1

      Status: PROVISIONAL

      Source sequence(s)
      BC071346
      UniProtKB/TrEMBL
      Q6IQQ8
      Related
      ENSDARP00000003875.6, ENSDART00000011192.8
      Conserved Domains (2) summary
      COG1184
      Location:23 → 291
      GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
      pfam01008
      Location:15 → 279
      IF-2B; Initiation factor 2 subunit family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      69641166..69649035 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009302036.4 → XP_009300311.1  translation initiation factor eIF2B subunit alpha isoform X1

      UniProtKB/TrEMBL
      A0A0R4ILD9, A0A8M3ASX8
      Related
      ENSDARP00000134906.1, ENSDART00000170885.3
      Conserved Domains (2) summary
      COG1184
      Location:23 → 302
      GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
      pfam01008
      Location:15 → 290
      IF-2B; Initiation factor 2 subunit family

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394622.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      19227..27032 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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