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    Prm2 protamine 2 [ Mus musculus (house mouse) ]

    Gene ID: 19119, updated on 9-Dec-2024

    Summary

    Official Symbol
    Prm2provided by MGI
    Official Full Name
    protamine 2provided by MGI
    Primary source
    MGI:MGI:97766
    See related
    Ensembl:ENSMUSG00000038015 AllianceGenome:MGI:97766
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Prm-2
    Summary
    Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis, and are the major DNA-binding proteins in the nucleus of sperm in many vertebrates. They package the sperm DNA into a highly condensed complex in a volume less than 5% of a somatic cell nucleus. Many mammalian species have only one protamine (protamine 1); however, a few species, including human and mouse, have two. This gene encodes protamine 2, which is synthesized as a precursor and then cleaved to give rise to a family of protamine 2 peptides. [provided by RefSeq, Sep 2015]
    Expression
    Restricted expression toward testis adult (RPKM 5910.5) See more
    Orthologs
    NEW
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    Genomic context

    See Prm2 in Genome Data Viewer
    Location:
    16 A1; 16 5.84 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (10609241..10609969, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (10791377..10792105, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene transition protein 2 Neighboring gene protamine 3 Neighboring gene protamine 1 Neighboring gene STARR-seq mESC enhancer starr_40096 Neighboring gene 60S ribosomal protein L30-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables cadmium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cadmium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within chromosome condensation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in nucleus organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within nucleus organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sequestering of metal ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in spermatid development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    NOT located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in male germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    part_of nucleosome IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    protamine-2
    Names
    sperm histone P2
    sperm protamine P2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008933.2NP_032959.1  protamine-2

      See identical proteins and their annotated locations for NP_032959.1

      Status: REVIEWED

      Source sequence(s)
      AK005729, AV207640
      Consensus CDS
      CCDS27955.1
      UniProtKB/Swiss-Prot
      P07978
      UniProtKB/TrEMBL
      C3U1R6, C3U1R7, C3U1R8, C3U1S0, Q545M0
      Related
      ENSMUSP00000047925.6, ENSMUST00000037996.7
      Conserved Domains (1) summary
      pfam00841
      Location:165
      Protamine_P2; Sperm histone P2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      10609241..10609969 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)