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    Abhd17c abhydrolase domain containing 17C [ Mus musculus (house mouse) ]

    Gene ID: 70178, updated on 27-Nov-2024

    Summary

    Official Symbol
    Abhd17cprovided by MGI
    Official Full Name
    abhydrolase domain containing 17Cprovided by MGI
    Primary source
    MGI:MGI:1917428
    See related
    Ensembl:ENSMUSG00000038459 AllianceGenome:MGI:1917428
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam108c; Fam108c1; 2210412D01Rik
    Summary
    Enables palmitoyl-(protein) hydrolase activity. Involved in negative regulation of protein localization to microtubule; positive regulation of protein localization to endosome; and protein depalmitoylation. Located in postsynaptic density. Is expressed in several structures, including alimentary system; cortical plate; cranial ganglion; genitourinary system; and skin. Orthologous to human ABHD17C (abhydrolase domain containing 17C, depalmitoylase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in small intestine adult (RPKM 86.1), colon adult (RPKM 84.3) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Abhd17c in Genome Data Viewer
    Location:
    7 D3; 7 48.35 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (83758564..83801101, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (84109356..84151893, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9696 Neighboring gene STARR-positive B cell enhancer ABC_E448 Neighboring gene talin rod domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_19417 Neighboring gene mesoderm development LRP chaperone Neighboring gene STARR-seq mESC enhancer starr_19418 Neighboring gene cell migration inducing protein, hyaluronan binding Neighboring gene STARR-seq mESC enhancer starr_19420 Neighboring gene predicted gene, 30440 Neighboring gene STARR-seq mESC enhancer starr_19424 Neighboring gene STARR-seq mESC enhancer starr_19425 Neighboring gene STARR-seq mESC enhancer starr_19426 Neighboring gene predicted gene, 26708 Neighboring gene predicted gene, 53174 Neighboring gene predicted gene, 39044 Neighboring gene predicted gene, 22177

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables palmitoyl-(protein) hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables palmitoyl-(protein) hydrolase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables palmitoyl-(protein) hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic density membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in recycling endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    alpha/beta hydrolase domain-containing protein 17C
    Names
    abhydrolase domain-containing protein 17C
    abhydrolase domain-containing protein FAM108C1
    family with sequence similarity 108, member C
    protein ABHD17C
    NP_598483.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133722.2NP_598483.2  alpha/beta hydrolase domain-containing protein 17C

      See identical proteins and their annotated locations for NP_598483.2

      Status: VALIDATED

      Source sequence(s)
      AC101659, AK008906, BM943880, BQ033953
      Consensus CDS
      CCDS21417.2
      UniProtKB/Swiss-Prot
      Q8VCV1
      Related
      ENSMUSP00000112988.2, ENSMUST00000117085.2
      Conserved Domains (1) summary
      COG1073
      Location:125317
      FrsA; Fermentation-respiration switch protein FrsA, has esterase activity, DUF1100 family [Signal transduction mechanisms]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      83758564..83801101 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)