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    Trp53rka transformation related protein 53 regulating kinase A [ Mus musculus (house mouse) ]

    Gene ID: 381406, updated on 9-Dec-2024

    Summary

    Official Symbol
    Trp53rkaprovided by MGI
    Official Full Name
    transformation related protein 53 regulating kinase Aprovided by MGI
    Primary source
    MGI:MGI:1918294
    See related
    Ensembl:ENSMUSG00000039725 AllianceGenome:MGI:1918294
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810408M09Rik
    Summary
    Predicted to enable p53 binding activity and protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation and tRNA threonylcarbamoyladenosine metabolic process. Predicted to be located in cytoplasm. Predicted to be part of EKC/KEOPS complex. Predicted to be active in cytosol and nucleus. Is expressed in embryo. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome 4. Orthologous to human TP53RK (TP53 regulating kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 16.1), CNS E11.5 (RPKM 14.2) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Trp53rka in Genome Data Viewer
    Location:
    2 H3; 2 85.64 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (165332032..165335244, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (165490112..165493314, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene osteoclast stimulatory transmembrane protein Neighboring gene solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 Neighboring gene origin of replication near adenosine deaminase Neighboring gene predicted gene 14437 Neighboring gene solute carrier family 2 (facilitated glucose transporter), member 10 Neighboring gene EYA transcriptional coactivator and phosphatase 2 Neighboring gene predicted gene, 29993

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    General gene information

    Clone Names

    • MGC102419

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables p53 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tRNA threonylcarbamoyladenosine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of EKC/KEOPS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of EKC/KEOPS complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    TP53-regulating kinase
    NP_001007582.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007581.2NP_001007582.1  TP53-regulating kinase

      See identical proteins and their annotated locations for NP_001007582.1

      Status: VALIDATED

      Source sequence(s)
      AL591064
      Consensus CDS
      CCDS17082.1
      UniProtKB/Swiss-Prot
      Q91W37, Q99PW4, Q9CZ32
      UniProtKB/TrEMBL
      Q5U452
      Related
      ENSMUSP00000045141.6, ENSMUST00000039007.7
      Conserved Domains (1) summary
      COG3642
      Location:27244
      Bud32; tRNA A-37 threonylcarbamoyl transferase component Bud32 [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      165332032..165335244 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)