U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    TAE1 N-terminal protein methyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852564, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    TAE1
    Official Full Name
    N-terminal protein methyltransferase
    Primary source
    SGD:S000000465
    Locus tag
    YBR261C
    See related
    AllianceGenome:SGD:S000000465; FungiDB:YBR261C; VEuPathDB:YBR261C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    NTM1
    Summary
    Enables N-terminal protein N-methyltransferase activity. Involved in N-terminal peptidyl-proline dimethylation and cytoplasmic translation. Located in cytosol. Orthologous to human NTMT1 (N-terminal Xaa-Pro-Lys N-methyltransferase 1) and NTMT2 (N-terminal Xaa-Pro-Lys N-methyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See TAE1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (734832..735530, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene GTPase-activating protein RGD1 Neighboring gene Mic12p Neighboring gene glycine hydroxymethyltransferase SHM1

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Discovering the N-Terminal Methylome by Repurposing of Proteomic Datasets. Chen P, et al. J Proteome Res, 2021 Sep 3. PMID 34382793
    2. Identification of protein N-terminal methyltransferases in yeast and humans. Webb KJ, et al. Biochemistry, 2010 Jun 29. PMID 20481588, Free PMC Article
    3. Ribosomal protein methyltransferases in the yeast Saccharomyces cerevisiae: Roles in ribosome biogenesis and translation. Al-Hadid Q, et al. Biochem Biophys Res Commun, 2016 Feb 12. PMID 26801560, Free PMC Article
    4. Chemical-genetic profile analysis in yeast suggests that a previously uncharacterized open reading frame, YBR261C, affects protein synthesis. Alamgir M, et al. BMC Genomics, 2008 Dec 3. PMID 19055778, Free PMC Article
    5. DBP7 and YRF1-6 Are Involved in Cell Sensitivity to LiCl by Regulating the Translation of PGM2 mRNA. Jagadeesan SK, et al. Int J Mol Sci, 2023 Jan 16. PMID 36675300, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. deletion of YBR261C alters the ribosomal profile of the mutant cells. Also, gene deletion strain for YBR261C has defects in both translation efficiency and fidelity
      Title: Chemical-genetic profile analysis in yeast suggests that a previously uncharacterized open reading frame, YBR261C, affects protein synthesis.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables N-terminal protein N-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-terminal protein N-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables N-terminal protein N-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables N-terminal protein N-methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-terminal peptidyl-proline dimethylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in N-terminal peptidyl-proline dimethylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic translation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cytoplasmic translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    N-terminal protein methyltransferase
    NP_009820.1
    • AdoMet-dependent proline methyltransferase; catalyzes the dimethylation of ribosomal proteins Rpl12 and Rps25 at N-terminal proline residues; has a role in protein synthesis; fusion protein localizes to the cytoplasm

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      734832..735530 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178609.1 → NP_009820.1  TPA: N-terminal protein methyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009820.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQQ8, P38340
      UniProtKB/TrEMBL
      A6ZLK1, B3LMQ0, B5VEL0, C7GMW9, D3UF09, G2W9R6, N1P8T9
      Conserved Domains (1) summary
      pfam05891
      Location:6 → 228
      Methyltransf_PK; AdoMet dependent proline di-methyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38340.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools