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    BAP2 branched-chain amino acid permease BAP2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852360, updated on 9-Dec-2024

    Summary

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    Official Symbol
    BAP2
    Official Full Name
    branched-chain amino acid permease BAP2
    Primary source
    SGD:S000000272
    Locus tag
    YBR068C
    See related
    AllianceGenome:SGD:S000000272; FungiDB:YBR068C; VEuPathDB:YBR068C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables amino acid transmembrane transporter activity. Involved in amino acid transport and transmembrane transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See BAP2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (373861..375690, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Nrg2p Neighboring gene putative lipase Neighboring gene amino acid transporter TAT1 Neighboring gene ncRNA Neighboring gene N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase anchoring subunit ALG14

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Amino acids induce expression of BAP2, a branched-chain amino acid permease gene in Saccharomyces cerevisiae. Didion T, et al. J Bacteriol, 1996 Apr. PMID 8606179, Free PMC Article
    2. The N-terminal domain of the yeast permease Bap2p plays a role in its degradation. Omura F, et al. Biochem Biophys Res Commun, 2001 Oct 12. PMID 11587526
    3. The branched-chain amino acid permease gene of Saccharomyces cerevisiae, BAP2, encodes the high-affinity leucine permease (S1). Schreve J, et al. Yeast, 1997 Apr. PMID 9153753
    4. The basal turnover of yeast branched-chain amino acid permease Bap2p requires its C-terminal tail. Omura F, et al. FEMS Microbiol Lett, 2001 Jan 15. PMID 11164310
    5. Linking gene expression and oenological traits: Comparison between Torulaspora delbrueckii and Saccharomyces cerevisiae strains. Tondini F, et al. Int J Food Microbiol, 2019 Apr 2. PMID 30763906

    See all (82) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Novel function of transcription factor Uga3 as an activator of branched-chain amino acid permease BAP2 gene expression.
      Title: Novel function of transcription factor Uga3 as an activator of branched-chain amino acid permease BAP2 gene expression.
    2. A regulatory circuit between lncRNA and TOR directs amino acid uptake in yeast.
      Title: A regulatory circuit between lncRNA and TOR directs amino acid uptake in yeast.
    3. Using in silico analyses and mutational studies we found that the C-terminal sequences of Gap1, Bap2, Hip1, Tat1, Tat2, Mmp1, Sam3, Agp1, and Gnp1 are about 50 residues long, associate with the Plasma Membrane , and have features that discriminate them from the termini of organellar amino acid transporters
      Title: A Plasma Membrane Association Module in Yeast Amino Acid Transporters.
    4. Ist2 in the yeast cortical endoplasmic reticulum promotes trafficking of the amino acid transporter Bap2 to the plasma membrane.
      Title: Ist2 in the yeast cortical endoplasmic reticulum promotes trafficking of the amino acid transporter Bap2 to the plasma membrane.
    5. The substrate partition efficiency to the buried Bap2 binding pocket is the primary determinant of substrate specificity.
      Title: Functional mapping and implications of substrate specificity of the yeast high-affinity leucine permease Bap2.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables amino acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in amino acid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phenylalanine transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    branched-chain amino acid permease BAP2
    NP_009624.4
    • High-affinity leucine permease; functions as a branched-chain amino acid permease involved in uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains; BAP2 has a paralog, BAP3, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      373861..375690 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178416.4 → NP_009624.4  TPA: branched-chain amino acid permease BAP2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009624.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQ67, P38084
      UniProtKB/TrEMBL
      A6ZL12, B3LN81, B5VE33, G2W973
      Conserved Domains (1) summary
      TIGR00913
      Location:92 → 573
      2A0310; amino acid permease (yeast)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38084.2

    Gene LinkOut

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