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    MPP6 Mpp6p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855758, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MPP6
    Official Full Name
    Mpp6p
    Primary source
    SGD:S000005307
    Locus tag
    YNR024W
    See related
    AllianceGenome:SGD:S000005307; FungiDB:YNR024W; VEuPathDB:YNR024W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables poly(U) RNA binding activity. Involved in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and nuclear RNA surveillance. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MPP6 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (672409..672969)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene mitochondrial 54S ribosomal protein MRPL50 Neighboring gene Snf12p Neighboring gene Sar family guanine nucleotide exchange factor SEC12 Neighboring gene putative pyridoxal kinase BUD17

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure and reconstitution of yeast Mpp6-nuclear exosome complexes reveals that Mpp6 stimulates RNA decay and recruits the Mtr4 helicase. Wasmuth EV, et al. Elife, 2017 Jul 25. PMID 28742025, Free PMC Article
    2. The exosome cofactor Rrp47 is critical for the stability and normal expression of its associated exoribonuclease Rrp6 in Saccharomyces cerevisiae. Feigenbutz M, et al. PLoS One, 2013. PMID 24224060, Free PMC Article
    3. Substrate discrimination and quality control require each catalytic activity of TRAMP and the nuclear RNA exosome. Das M, et al. Proc Natl Acad Sci U S A, 2021 Apr 6. PMID 33782132, Free PMC Article
    4. The exosome-binding factors Rrp6 and Rrp47 form a composite surface for recruiting the Mtr4 helicase. Schuch B, et al. EMBO J, 2014 Dec 1. PMID 25319414, Free PMC Article
    5. In vivo characterization of the critical interaction between the RNA exosome and the essential RNA helicase Mtr4 in Saccharomyces cerevisiae. Sterrett MC, et al. G3 (Bethesda), 2023 Aug 9. PMID 36861343, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mpp6-exosomes can recruit Mtr4, while Mpp6 and Rrp47 each contribute to Mtr4-dependent RNA decay, with maximal Mtr4-dependent decay observed with both cofactors.
      Title: Structure and reconstitution of yeast Mpp6-nuclear exosome complexes reveals that Mpp6 stimulates RNA decay and recruits the Mtr4 helicase.
    2. Cotranscriptional recruitment of RNA exosome cofactors Rrp47p and Mpp6p and two distinct Trf-Air-Mtr4 polyadenylation (TRAMP) complexes assists the exonuclease Rrp6p in the targeting and degradation of an aberrant messenger
      Title: Cotranscriptional recruitment of RNA exosome cofactors Rrp47p and Mpp6p and two distinct Trf-Air-Mtr4 polyadenylation (TRAMP) complexes assists the exonuclease Rrp6p in the targeting and degradation of an aberrant messenger ribonucleoprotein particle (mRNP) in yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(U) RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear mRNA surveillance of mRNA 3'-end processing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nuclear mRNA surveillance of spliceosomal pre-mRNA splicing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nuclear polyadenylation-dependent CUT catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nuclear polyadenylation-dependent CUT catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear polyadenylation-dependent rRNA catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mpp6p
    NP_014421.3
    • Nuclear exosome-associated RNA binding protein; involved in surveillance of pre-rRNAs and pre-mRNAs, and the degradation of cryptic non-coding RNAs (ncRNA); copurifies with ribosomes; relocalizes to the cytosol in response to hypoxia

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      672409..672969
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183201.3 → NP_014421.3  TPA: Mpp6p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014421.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1J9, P53725
      UniProtKB/TrEMBL
      A6ZS98, B3LPL9, C7GLN3, C8ZFQ1, G2WL81, N1NWT3
      Conserved Domains (1) summary
      pfam10175
      Location:9 → 181
      MPP6; M-phase phosphoprotein 6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53725.1

    Gene LinkOut

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