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    RPL2A ribosomal 60S subunit protein L2A [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850590, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RPL2A
    Official Full Name
    ribosomal 60S subunit protein L2A
    Primary source
    SGD:S000002104
    Locus tag
    YFR031C-A
    See related
    AllianceGenome:SGD:S000002104; FungiDB:YFR031C-A; VEuPathDB:YFR031C-A
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    RPL5B
    Summary
    A structural constituent of ribosome. Involved in cytoplasmic translation; maintenance of translational fidelity; and ribosomal large subunit biogenesis. Part of cytosolic large ribosomal subunit. Used to study Diamond-Blackfan anemia. Orthologous to human RPL8 (ribosomal protein L8). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RPL2A in Genome Data Viewer
    Location:
    chromosome: VI
    Exon count:
    2
    Sequence:
    Chromosome: VI; NC_001138.5 (220507..221418, complement)

    Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene sulfite reductase subunit alpha Neighboring gene condensin subunit SMC2 Neighboring gene ncRNA Neighboring gene Rrt5p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001138.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure/function analysis of yeast ribosomal protein L2. Meskauskas A, et al. Nucleic Acids Res, 2008 Apr. PMID 18263608, Free PMC Article
    2. The ABF1 factor is the transcriptional activator of the L2 ribosomal protein genes in Saccharomyces cerevisiae. Della Seta F, et al. Mol Cell Biol, 1990 May. PMID 2183035, Free PMC Article
    3. Characterisation of Saccharomyces cerevisiae genes encoding ribosomal protein YL6. Moore J, et al. Mol Gen Genet, 1995 Apr 20. PMID 7753035
    4. The amino terminal domain from Mrt4 protein can functionally replace the RNA binding domain of the ribosomal P0 protein. Rodríguez-Mateos M, et al. Nucleic Acids Res, 2009 Jun. PMID 19346338, Free PMC Article
    5. Introns provide a platform for intergenic regulatory feedback of RPL22 paralogs in yeast. Abrhámová K, et al. PLoS One, 2018. PMID 29304067, Free PMC Article

    See all (108) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables rRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in maintenance of translational fidelity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal large subunit biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosolic ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal 60S subunit protein L2A
    NP_116688.3
    • Ribosomal 60S subunit protein L2A; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2A has a paralog, RPL2B, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001138.5 Reference assembly

      Range
      220507..221418 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180030.3 → NP_116688.3  TPA: ribosomal 60S subunit protein L2A [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_116688.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTR2, P05736, P0CX45, P0CX46
      UniProtKB/TrEMBL
      A6ZVP9, B3LTM6, B3LUP0, C8Z7W6, G2WGC6, N1P6U2
      Conserved Domains (1) summary
      cl40667
      Location:1 → 252
      RplB; Ribosomal protein L2 [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0CX45.1
    P0CX46.1

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