SEC7 Arf family guanine nucleotide exchange factor SEC7 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SEC7
Official Full Name: Arf family guanine nucleotide exchange factor SEC7
Primary source: SGD:S000002577
Locus tag: YDR170C
See related: AllianceGenome:SGD:S000002577; FungiDB:YDR170C; VEuPathDB:YDR170C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables guanyl-nucleotide exchange factor activity. Involved in autophagosome assembly; endoplasmic reticulum to Golgi vesicle-mediated transport; and intra-Golgi vesicle-mediated transport. Acts upstream of or within cytoplasm protein quality control. Located in cytoplasmic vesicle; cytosol; and trans-Golgi network. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to human ARFGEF1 (ARF guanine nucleotide exchange factor 1) and ARFGEF2 (ARF guanine nucleotide exchange factor 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See SEC7 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (796193..802222, complement)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The yeast guanine nucleotide exchange factor Sec7 is a bottleneck in spatial protein quality control and detoxifies neurological disease proteins.
Title: The yeast guanine nucleotide exchange factor Sec7 is a bottleneck in spatial protein quality control and detoxifies neurological disease proteins.
results support a model in which the inter- and intramolecular interactions of the homology upstream of Sec7 ( HUS) box and the C terminus are necessary for the allosteric activation of Sec7.
Title: The HUS box is required for allosteric regulation of the Sec7 Arf-GEF.
The DCB/HUS domain amplifies the ability of Sec7 to activate Arf1 on the membrane surface by facilitating membrane insertion of the Arf1 amphipathic helix.
Title: The Sec7 N-terminal regulatory domains facilitate membrane-proximal activation of the Arf1 GTPase.
Sec7 is an effector of the Ypt1 and Ypt31/32 GTPases.
Title: Four GTPases differentially regulate the Sec7 Arf-GEF to direct traffic at the trans-golgi network.
Crystallographic, NMR spectrum and mutagenesis studies suggested that the loop>J motif with a key conserved residue Ile1010 modulates the fine conformation of Sec7 domain and thereby regulates its guanine exchange activity.
Title: C-terminal motif within Sec7 domain regulates guanine nucleotide exchange activity via tuning protein conformation.
analysis of the C-terminal sequence in the guanine nucleotide exchange factor Sec7 that mediates Golgi association and interaction with the Rsp5 ubiquitin ligase
Title: A C-terminal sequence in the guanine nucleotide exchange factor Sec7 mediates Golgi association and interaction with the Rsp5 ubiquitin ligase.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IDA Inferred from Direct Assay more info	PubMed
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in autophagosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cytoplasm protein quality control	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intra-Golgi vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of ARF protein signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in COPI-coated vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in ER to Golgi transport vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi-associated vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Arf family guanine nucleotide exchange factor SEC7

NP_010454.3

Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors; involved in intra-Golgi transport, ER-to-Golgi transport and proliferation of the Golgi; role in directing misfolded proteins to insoluble deposition sites and detoxifying neurological disease proteins; found in the cytoplasm and on Golgi-associated coated vesicles

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

796193..802222 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180477.3 → NP_010454.3 TPA: Arf family guanine nucleotide exchange factor SEC7 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010454.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VSF1, P11075, Q03960, Q04139

UniProtKB/TrEMBL

A6ZYC8

Conserved Domains (2) summary

COG5307
Location:504 → 1693

COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]

pfam16213
Location:283 → 426

DCB; dimerization and cyclophilin-binding domain of Mon2