GCD11 translation initiation factor eIF2 subunit gamma [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: GCD11
Official Full Name: translation initiation factor eIF2 subunit gamma
Primary source: SGD:S000000827
Locus tag: YER025W
See related: AllianceGenome:SGD:S000000827; FungiDB:YER025W; VEuPathDB:YER025W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: SUI4
Summary: Enables translation initiation factor activity and translation initiation factor binding activity. Contributes to GTP binding activity and methionyl-initiator methionine tRNA binding activity. Involved in formation of translation preinitiation complex and positive regulation of translational fidelity. Located in cytosol. Part of several cellular components, including eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; and eukaryotic translation initiation factor 2 complex. Used to study MEHMO syndrome; glucose metabolism disease; hypopituitarism; and leukodystrophy. Human ortholog(s) of this gene implicated in MEHMO syndrome. Orthologous to human EIF2S3 (eukaryotic translation initiation factor 2 subunit gamma) and EIF2S3B (eukaryotic translation initiation factor 2 subunit gamma B). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See GCD11 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 1

Sequence:: Chromosome: V; NC_001137.3 (205251..206834)

Chromosome V - NC_001137.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that Cdc123 is a specific assembly factor for eukaryotic translation initiation factor 2 (eIF) subunit alpha (sui2), subunit beta (sui3) and subunit gamma (GCD11), which is indispensable for the onset of protein synthesis.
Title: Translation initiation requires cell division cycle 123 (Cdc123) to facilitate biogenesis of the eukaryotic initiation factor 2 (eIF2).
Data suggest that structural alterations in eIF2gamma subtly alter the conformation of Met-tRNA(i)(Met) on the 40S subunit and thereby affect the fidelity of start codon recognition independent of Met-tRNA(i)(Met) binding affinity.
Title: Translation initiation factor 2gamma mutant alters start codon selection independent of Met-tRNA binding.
the Cdc123-Chf-Gcd11 axis is an essential pathway for nutritional control of START that runs parallel to the Tor-Gcn2-Sui2 system of translational control
Title: Cdc123 and checkpoint forkhead associated with RING proteins control the cell cycle by controlling eIF2gamma abundance.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
contributes_to GTP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTP binding	IEA Inferred from Electronic Annotation more info
contributes_to GTP binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables membrane scission GTPase motor activity	IEA Inferred from Electronic Annotation more info
contributes_to methionyl-initiator methionine tRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to tRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables tRNA binding	IEA Inferred from Electronic Annotation more info
contributes_to tRNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info
enables translation initiation factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables translation initiation factor binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in formation of translation preinitiation complex	IBA Inferred from Biological aspect of Ancestor more info
involved_in formation of translation preinitiation complex	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of translational fidelity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in translation	IEA Inferred from Electronic Annotation more info
involved_in translational initiation	IEA Inferred from Electronic Annotation more info
involved_in translational initiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	HDA more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
part_of eukaryotic 43S preinitiation complex	IDA Inferred from Direct Assay more info	PubMed
part_of eukaryotic 48S preinitiation complex	IDA Inferred from Direct Assay more info	PubMed
part_of eukaryotic translation initiation factor 2 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of eukaryotic translation initiation factor 2 complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of multi-eIF complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: translation initiation factor eIF2 subunit gamma

NP_010942.1

EC 3.6.5.3

Gamma subunit of the translation initiation factor eIF2; involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met; mutations in human ortholog cause X-linked intellectual disability (XLID) syndrome

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001137.3 Reference assembly

Range

205251..206834

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178916.1 → NP_010942.1 TPA: translation initiation factor eIF2 subunit gamma [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010942.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DLS4, P32481

UniProtKB/TrEMBL

A6ZQX4, B3LS38, B5VHF9, C7GTD7, C8Z727, G2WCQ8, N1PA85

Conserved Domains (1) summary

PTZ00327
Location:74 → 524

PTZ00327; eukaryotic translation initiation factor 2 gamma subunit; Provisional