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    Galk1 galactokinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 14635, updated on 9-Dec-2024

    Summary

    Official Symbol
    Galk1provided by MGI
    Official Full Name
    galactokinase 1provided by MGI
    Primary source
    MGI:MGI:95730
    See related
    Ensembl:ENSMUSG00000020766 AllianceGenome:MGI:95730
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gk; Glk; GALK; Glk1
    Summary
    Enables galactokinase activity. Involved in galactose catabolic process via UDP-galactose. Acts upstream of or within galactitol metabolic process and glycolytic process from galactose. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in cataract and galactokinase deficiency. Orthologous to human GALK1 (galactokinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 109.7), liver E18 (RPKM 50.3) and 24 other tissues See more
    Orthologs
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    Genomic context

    See Galk1 in Genome Data Viewer
    Location:
    11 E2; 11 80.91 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (115899183..115903545, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (116008357..116012719, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene SAP30 binding protein Neighboring gene STARR-seq mESC enhancer starr_31181 Neighboring gene predicted gene, 39474 Neighboring gene STARR-seq mESC enhancer starr_31187 Neighboring gene RIKEN cDNA B230344G16 gene Neighboring gene integrin beta 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115873522-115873709 Neighboring gene STARR-positive B cell enhancer ABC_E306 Neighboring gene STARR-seq mESC enhancer starr_31191 Neighboring gene H3.3 histone B Neighboring gene unkempt family zinc finger Neighboring gene predicted gene, 38482

    Genomic regions, transcripts, and products

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP binding  
    enables galactokinase activity  
    enables galactokinase activity PubMed 
    enables galactokinase activity  
    enables galactose binding  
    enables galactose binding  
    enables protein binding PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in cytoplasm  
    is_active_in cytosol  

    General protein information

    Preferred Names
    galactokinase
    Names
    galactose kinase
    NP_058601.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016905.2NP_058601.2  galactokinase

      See identical proteins and their annotated locations for NP_058601.2

      Status: VALIDATED

      Source sequence(s)
      AK011103, AK045694, BB771442
      Consensus CDS
      CCDS25654.1
      UniProtKB/Swiss-Prot
      Q9JIA6, Q9R0N0
      UniProtKB/TrEMBL
      Q80UL3, Q9CXZ9
      Related
      ENSMUSP00000021114.5, ENSMUST00000021114.5
      Conserved Domains (4) summary
      PRK05101
      Location:12390
      PRK05101; galactokinase; Provisional
      pfam00288
      Location:128193
      GHMP_kinases_N; GHMP kinases N terminal domain
      pfam08544
      Location:291372
      GHMP_kinases_C; GHMP kinases C terminal
      pfam10509
      Location:1967
      GalKase_gal_bdg; Galactokinase galactose-binding signature

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      115899183..115903545 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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