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    ksr-2 Kinase suppressor of Ras B [ Caenorhabditis elegans ]

    Gene ID: 173085, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ksr-2
    Official Full Name
    Kinase suppressor of Ras B
    Primary source
    WormBase:WBGene00002240
    Locus tag
    CELE_F58D5.4
    See related
    AllianceGenome:WB:WBGene00002240
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables protein kinase activity. Involved in several processes, including Ras protein signal transduction; nematode male tail tip morphogenesis; and positive regulation of vulval development. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in breast adenocarcinoma. Orthologous to human KSR1 (kinase suppressor of ras 1) and KSR2 (kinase suppressor of ras 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ksr-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (12047342..12059798, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Cystatin domain-containing protein Neighboring gene RRM domain-containing protein Neighboring gene ncRNA Neighboring gene tRNA-Val

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Coordination of Recombination with Meiotic Progression in the Caenorhabditis elegans Germline by KIN-18, a TAO Kinase That Regulates the Timing of MPK-1 Signaling. Yin Y, et al. Genetics, 2016 Jan. PMID 26510792, Free PMC Article
    2. Regulation of response to nanopolystyrene by intestinal microRNA mir-35 in nematode Caenorhabditis elegans. Li D, et al. Sci Total Environ, 2020 Sep 20. PMID 32473456
    3. The NM23-H1/H2 homolog NDK-1 is required for full activation of Ras signaling in C. elegans. Masoudi N, et al. Development, 2013 Aug. PMID 23900546, Free PMC Article
    4. Nanoplastics cause transgenerational toxicity through inhibiting germline microRNA mir-38 in C. elegans. Hua X, et al. J Hazard Mater, 2022 Sep 5. PMID 35716568
    5. The germinal center kinase GCK-1 is a negative regulator of MAP kinase activation and apoptosis in the C. elegans germline. Schouest KR, et al. PLoS One, 2009 Oct 14. PMID 19826475, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Ras protein signal transduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode larval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nematode male tail tip morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of vulval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vulval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Kinase suppressor of Ras B
    NP_001021518.1
    • Confirmed by transcript evidence
    NP_001021519.1
    • Confirmed by transcript evidence
    NP_001129779.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      12047342..12059798 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001026347.6 → NP_001021518.1  Kinase suppressor of Ras B [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021518.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3KYC3, G5EDA5, G5EEY7
      Conserved Domains (3) summary
      cd14063
      Location:247 → 533
      PK_KSR; Pseudokinase domain of Kinase Suppressor of Ras
      pfam07714
      Location:253 → 526
      Pkinase_Tyr; Protein tyrosine kinase
      cl00040
      Location:103 → 145
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

    2. NM_001026348.4 → NP_001021519.1  Kinase suppressor of Ras B [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021519.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EDA5
      Conserved Domains (3) summary
      pfam07714
      Location:213 → 486
      Pkinase_Tyr; Protein tyrosine kinase
      cl00040
      Location:99 → 141
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl21453
      Location:207 → 493
      PKc_like; Protein Kinases, catalytic domain

    3. NM_001136307.4 → NP_001129779.1  Kinase suppressor of Ras B [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001129779.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EDA5
      Conserved Domains (3) summary
      pfam07714
      Location:161 → 434
      Pkinase_Tyr; Protein tyrosine kinase
      cl00040
      Location:11 → 53
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl21453
      Location:155 → 441
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EDA5.1

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