calu-1 EF-hand domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: calu-1
Official Full Name: EF-hand domain-containing protein
Primary source: WormBase:WBGene00019760
Locus tag: CELE_M03F4.7
See related: AllianceGenome:WB:WBGene00019760
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables calcium ion binding activity. Involved in cuticle development. Located in endoplasmic reticulum. Is expressed in several structures, including AIA; hypodermis; intestine; pharynx; and reproductive system. Orthologous to several human genes including CALU (calumenin). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See calu-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 3

Sequence:: Chromosome: X; NC_003284.9 (4969529..4970913, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Unlike its human homologue, calumenin from Caenorhabditis elegans (CeCalu) is structured even in the apo form, with no conformational change upon binding of Ca(2+). This is due to a single "Leu" residue-based switch located in the fourth EF-hand of human Calu1, occupied by "Gly" in the invertebrate homologues.
Title: The Differential Response to Ca(2+) from Vertebrate and Invertebrate Calumenin Is Governed by a Single Amino Acid Residue.
calumenin is important for calcium signaling pathways in C. elegans.
Title: Pleiotropic roles of calumenin (calu-1), a calcium-binding ER luminal protein, in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

M03F4.7 (e-PCR)
- UniSTS:311981

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in IRE1-mediated unfolded protein response	HEP more info	PubMed
involved_in cuticle development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	HDA more info	PubMed
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: EF-hand domain-containing protein

NP_001370866.1

Confirmed by transcript evidence

NP_001370867.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

4969529..4970913 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001383569.1 → NP_001370867.1 EF-hand domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

H2L0I1

Conserved Domains (2) summary

cd15899
Location:29 → 58

EFh_CREC; EF-hand motif [structural motif]

cl25354
Location:29 → 66

EFh_CREC; EF-hand, calcium binding motif, found in CREC-EF hand family
NM_001383568.2 → NP_001370866.1 EF-hand domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

G5EBH7

Conserved Domains (1) summary

cd16226
Location:29 → 296

EFh_CREC_Calumenin_like; EF-hand, calcium binding motif, found in calumenin, reticulocalbin-1 (RCN-1), reticulocalbin-3 (RCN-3), and similar proteins