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    cpsf-1 Cleavage/polyadenylation specificity factor A subunit C-terminal domain-containing protein;MMS1_N domain-containing protein;putative cleavage and polyadenylation specificity factor subunit 1 [ Caenorhabditis elegans ]

    Gene ID: 177003, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cpsf-1
    Official Full Name
    Cleavage/polyadenylation specificity factor A subunit C-terminal domain-containing protein;MMS1_N domain-containing protein;putative cleavage and polyadenylation specificity factor subunit 1
    Primary source
    WormBase:WBGene00022301
    Locus tag
    CELE_Y76B12C.7
    See related
    AllianceGenome:WB:WBGene00022301
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in mRNA processing. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in myopia. Orthologous to human CPSF1 (cleavage and polyadenylation specific factor 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cpsf-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    16
    Sequence:
    Chromosome: IV; NC_003282.8 (2009038..2032996, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene TPR_REGION domain-containing protein Neighboring gene ncRNA Neighboring gene XPC (Xeroderma Pigmentosum group C) DNA repair gene homolog Neighboring gene NUP50 domain-containing protein Neighboring gene Cyclic nucleotide-binding domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The C. elegans 3' UTRome v2 resource for studying mRNA cleavage and polyadenylation, 3'-UTR biology, and miRNA targeting. Steber HS, et al. Genome Res, 2019 Dec. PMID 31744903, Free PMC Article
    2. Different Mi-2 complexes for various developmental functions in Caenorhabditis elegans. Passannante M, et al. PLoS One, 2010 Oct 27. PMID 21060680, Free PMC Article
    3. Genes involved in pre-mRNA 3'-end formation and transcription termination revealed by a lin-15 operon Muv suppressor screen. Cui M, et al. Proc Natl Acad Sci U S A, 2008 Oct 28. PMID 18946043, Free PMC Article
    4. The ribonucleotidyl transferase USIP-1 acts with SART3 to promote U6 snRNA recycling. Rüegger S, et al. Nucleic Acids Res, 2015 Mar 31. PMID 25753661, Free PMC Article
    5. DEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegans. Suen KM, et al. Nat Commun, 2020 Aug 25. PMID 32843637, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of mRNA cleavage and polyadenylation specificity factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cleavage/polyadenylation specificity factor A subunit C-terminal domain-containing protein;MMS1_N domain-containing protein;putative cleavage and polyadenylation specificity factor subunit 1
    NP_001368311.1
    • Confirmed by transcript evidence
    NP_001368312.1
    • Confirmed by transcript evidence
    NP_001368313.1
    • Confirmed by transcript evidence
    NP_500157.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      2009038..2032996 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067756.6 → NP_500157.2  putative cleavage and polyadenylation specificity factor subunit 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500157.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9N4C2
      Conserved Domains (3) summary
      COG5161
      Location:10 → 1447
      SFT1; Pre-mRNA cleavage and polyadenylation specificity factor [RNA processing and modification]
      pfam03178
      Location:1079 → 1420
      CPSF_A; CPSF A subunit region
      pfam10433
      Location:93 → 623
      MMS1_N; Mono-functional DNA-alkylating methyl methanesulfonate N-term

    2. NM_001380077.1 → NP_001368311.1  MMS1_N domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PCC4
      Conserved Domains (2) summary
      COG5161
      Location:1 → 1256
      SFT1; Pre-mRNA cleavage and polyadenylation specificity factor [RNA processing and modification]
      pfam03178
      Location:888 → 1229
      CPSF_A; CPSF A subunit region

    3. NM_001380079.1 → NP_001368312.1  Cleavage/polyadenylation specificity factor A subunit C-terminal domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PMR4
      Conserved Domains (1) summary
      pfam03178
      Location:2 → 318
      CPSF_A; CPSF A subunit region

    4. NM_001380080.1 → NP_001368313.1  Cleavage/polyadenylation specificity factor A subunit C-terminal domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PS25
      Conserved Domains (1) summary
      pfam03178
      Location:3 → 77
      CPSF_A; CPSF A subunit region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9N4C2.2

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