ogt-1 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase;protein O-GlcNAc transferase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ogt-1
Official Full Name: UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase;protein O-GlcNAc transferase
Primary source: WormBase:WBGene00003858
Locus tag: CELE_K04G7.3
See related: AllianceGenome:WB:WBGene00003858
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables protein N-acetylglucosaminyltransferase activity; protein O-acetylglucosaminyltransferase activity; and protein serine/threonine phosphatase activity. Involved in several processes, including dauer larval development; glycogen metabolic process; and lipid storage. Located in nucleus and perinuclear region of cytoplasm. Is expressed in several structures, including intestine. Used to study diabetes mellitus and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 106. Orthologous to human OGT (O-linked N-acetylglucosamine (GlcNAc) transferase). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See ogt-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 13

Sequence:: Chromosome: III; NC_003281.10 (7145842..7153797, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

OGT-1 regulates synaptic assembly through the insulin signaling pathway.
Title: OGT-1 regulates synaptic assembly through the insulin signaling pathway.
O-GlcNAc transferase OGT-1 and the ubiquitin ligase EEL-1 modulate seizure susceptibility in C. elegans.
Title: O-GlcNAc transferase OGT-1 and the ubiquitin ligase EEL-1 modulate seizure susceptibility in C. elegans.
The O-GlcNAc transferase OGT is a conserved and essential regulator of the cellular and organismal response to hypertonic stress.
Title: The O-GlcNAc transferase OGT is a conserved and essential regulator of the cellular and organismal response to hypertonic stress.
findings demonstrate that OGT-1 and EEL-1 form a conserved signaling complex and function together to affect GABA neuron function
Title: A complex containing the O-GlcNAc transferase OGT-1 and the ubiquitin ligase EEL-1 regulates GABA neuron function.
The Caenorhabditis elegans orthologues of Ca(2+)/calmodulin-dependent kinases CaMK1/4, CMK-1, and O-linked N-acetylglucosamine (O-GlcNAc) transferase, OGT-1, both function in primary sensory neurons to inhibit habituation at short interstimulus interval (ISI) and promote it at long ISIs.
Title: Insights into the roles of CMK-1 and OGT-1 in interstimulus interval-dependent habituation in Caenorhabditis elegans.
The participation of nutrient sensor OGT-1 in an immunity module evolutionarily conserved from C. elegans to humans reveals an unexplored nexus between nutrient availability and a pathogen-specific immune response.
Title: Conserved nutrient sensor O-GlcNAc transferase is integral to C. elegans pathogen-specific immunity.
Data show that glucose stress, oga-1 mutants, and ogt-1 mutants each result in an increase in daf-2 carbohydrate storage.
Title: O-linked-N-acetylglucosamine cycling and insulin signaling are required for the glucose stress response in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K04G7.3 (e-PCR)
- UniSTS:311413

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein N-acetylglucosaminyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein N-acetylglucosaminyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein O-acetylglucosaminyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein O-acetylglucosaminyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein O-acetylglucosaminyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein serine/threonine phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in UDP-N-acetylglucosamine biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in dauer larval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in energy reserve metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycogen metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycoprotein metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid storage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein O-linked glycosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein O-linked glycosylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info
involved_in reproductive process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to temperature stimulus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase;protein O-GlcNAc transferase

NP_001040860.1

Confirmed by transcript evidence

NP_001040861.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

7145842..7153797 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001047395.5 → NP_001040860.1 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

O18158, Q21232

Conserved Domains (8) summary

COG0457
Location:308 → 565

TPR; Tetratricopeptide (TPR) repeat [General function prediction only]

sd00006
Location:465 → 493

TPR; TPR repeat [structural motif]

cd15832
Location:330 → 375

SNAP; TPR repeat [structural motif]

pfam00515
Location:499 → 530

TPR_1; Tetratricopeptide repeat

pfam13414
Location:193 → 258

TPR_11; TPR repeat

pfam13424
Location:257 → 327

TPR_12; Tetratricopeptide repeat

pfam13844
Location:663 → 1129

Glyco_transf_41; Glycosyl transferase family 41

cl24038
Location:330 → 534

SNAP; Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family
NM_001047396.5 → NP_001040861.1 protein O-GlcNAc transferase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q2L6Y4

Conserved Domains (3) summary

TIGR02917
Location:21 → 422

PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein

sd00006
Location:287 → 315

TPR; TPR repeat [structural motif]

pfam13844
Location:485 → 951

Glyco_transf_41; Glycosyl transferase family 41