U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    sca-1 Calcium-transporting ATPase [ Caenorhabditis elegans ]

    Gene ID: 176512, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    sca-1
    Official Full Name
    Calcium-transporting ATPase
    Primary source
    WormBase:WBGene00004736
    Locus tag
    CELE_K11D9.2
    See related
    AllianceGenome:WB:WBGene00004736
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables P-type calcium transporter activity and chromatin DNA binding activity. Involved in several processes, including IRE1-mediated unfolded protein response; determination of adult lifespan; and multicellular organismal-level water homeostasis. Located in several cellular components, including nuclear envelope; nuclear outer membrane-endoplasmic reticulum membrane network; and sarcoplasmic reticulum. Is expressed in several structures, including egg-laying apparatus; excretory system; intestine; non-striated muscle; and spermatheca. Human ortholog(s) of this gene implicated in Brody myopathy; acrokeratosis verruciformis; essential hypertension; keratosis follicularis; and pulmonary hypertension. Orthologous to several human genes including ATP2A3 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See sca-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    8
    Sequence:
    Chromosome: III; NC_003281.10 (10811906..10816844, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Kinesin-like protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Two isoforms of sarco/endoplasmic reticulum calcium ATPase (SERCA) are essential in Caenorhabditis elegans. Cho JH, et al. Gene, 2000 Dec 31. PMID 11167007
    2. The sarco-endoplasmic reticulum Ca2+ ATPase is required for development and muscle function in Caenorhabditis elegans. Zwaal RR, et al. J Biol Chem, 2001 Nov 23. PMID 11559701
    3. Microbiota and Diapause-Induced Neuroprotection Share a Dependency on Calcium But Differ in Their Effects on Mitochondrial Morphology. Delgado SE, et al. eNeuro, 2023 Jul. PMID 37385728, Free PMC Article
    4. mir-233 modulates the unfolded protein response in C. elegans during Pseudomonas aeruginosa infection. Dai LL, et al. PLoS Pathog, 2015 Jan. PMID 25569229, Free PMC Article
    5. The sarco(endo)plasmic reticulum calcium ATPase SCA-1 regulates the Caenorhabditis elegans nicotinic acetylcholine receptor ACR-16. Martin AA, et al. Cell Calcium, 2018 Jun. PMID 29748129

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Changes in cytosolic baseline calcium levels in sca-1 and other mutants indicates a calcium-driven regulation mechanism of the alpha7-like NAChR ACR-16.
      Title: The sarco(endo)plasmic reticulum calcium ATPase SCA-1 regulates the Caenorhabditis elegans nicotinic acetylcholine receptor ACR-16.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type calcium transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables P-type calcium transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables P-type calcium transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin DNA binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in IRE1-mediated unfolded protein response HEP PubMed 
    involved_in IRE1-mediated unfolded protein response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in calcium ion import IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in calcium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dauer larval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum unfolded protein response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in intracellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular calcium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in multicellular organismal-level water homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear outer membrane-endoplasmic reticulum membrane network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sarcoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sarcoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sarcoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Calcium-transporting ATPase
    NP_001122708.1
    • Partially confirmed by transcript evidence
    NP_499385.3
    • Confirmed by transcript evidence
    NP_499386.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      10811906..10816844 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066984.9 → NP_499385.3  Calcium-transporting ATPase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499385.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XU13
      Conserved Domains (6) summary
      TIGR01116
      Location:52 → 990
      ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
      pfam00122
      Location:95 → 342
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:785 → 988
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:4 → 71
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12710
      Location:607 → 713
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:423 → 529
      Cation_ATPase; Cation transport ATPase (P-type)

    2. NM_066985.7 → NP_499386.1  Calcium-transporting ATPase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499386.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EEK8
      Conserved Domains (6) summary
      TIGR01116
      Location:52 → 990
      ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
      pfam00122
      Location:95 → 342
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:785 → 988
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:4 → 71
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12710
      Location:607 → 713
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:423 → 529
      Cation_ATPase; Cation transport ATPase (P-type)

    3. NM_001129236.4 → NP_001122708.1  Calcium-transporting ATPase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122708.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8WI68
      Conserved Domains (5) summary
      TIGR01116
      Location:1 → 863
      ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
      pfam00122
      Location:2 → 215
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:658 → 861
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam12710
      Location:480 → 586
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:296 → 402
      Cation_ATPase; Cation transport ATPase (P-type)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous