zyg-1 putative serine/threonine-protein kinase zyg-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: zyg-1
Official Full Name: putative serine/threonine-protein kinase zyg-1
Primary source: WormBase:WBGene00006988
Locus tag: CELE_F59E12.2
See related: AllianceGenome:WB:WBGene00006988
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables identical protein binding activity and protein serine/threonine kinase activity. Involved in several processes, including non-membrane-bounded organelle assembly; positive regulation of cell cycle; and regulation of protein localization. Located in centriole and centrosome. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See zyg-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 7

Sequence:: Chromosome: II; NC_003280.10 (5649748..5654422)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The kinase ZYG-1 phosphorylates the cartwheel protein SAS-5 to drive centriole assembly in C. elegans.
Title: The kinase ZYG-1 phosphorylates the cartwheel protein SAS-5 to drive centriole assembly in C. elegans.
APC/CFZR-1 regulates centrosomal ZYG-1 to limit centrosome number.
Title: APC/CFZR-1 regulates centrosomal ZYG-1 to limit centrosome number.
These findings lead us to conclude that ZYG-1 promotes limited centriole amplification solely during the symmetric division in the C. elegans seam lineage.
Title: ZYG-1 promotes limited centriole amplification in the C. elegans seam lineage.
Structure of the C. elegans ZYG-1 cryptic polo box suggests a conserved mechanism for centriolar docking of Plk4 kinases.
Title: Structure of the C. elegans ZYG-1 cryptic polo box suggests a conserved mechanism for centriolar docking of Plk4 kinases.
Direct interactions of the SAS-6 coiled coil with ZYG-1 and SAS-5 are required to recruit SAS-6 to the mother centriole.
Title: Direct binding of SAS-6 to ZYG-1 recruits SAS-6 to the mother centriole for cartwheel assembly.
Data show that levels of the C. elegans Plk4 homolog ZYG-1 are elevated by impairing proteasome or SCF function, indicating that ZYG-1 is regulated by a conserved mechanism.
Title: The C. elegans F-box proteins LIN-23 and SEL-10 antagonize centrosome duplication by regulating ZYG-1 levels.
Data reveal differences in the regulation of mitotic and meiotic centrosome duplication, particularly with regard to ZYG-1 activity, and reveal an important role for centrosomes in spermatid formation.
Title: Control of mitotic and meiotic centriole duplication by the Plk4-related kinase ZYG-1.
Study demonstrates that the kinase ZYG-1 phosphorylates the coiled-coil protein SAS-6 at serine 123 in vitro; this phosphorylation event is crucial for centriole formation in vivo.
Title: Phosphorylation of SAS-6 by ZYG-1 is critical for centriole formation in C. elegans embryos.
SZY-20 opposes the Plk4-related kinase ZYG-1 to limit centrosome size
Title: The conserved protein SZY-20 opposes the Plk4-related kinase ZYG-1 to limit centrosome size.
Numerous candidate regulators of centrosome duplication and regulatory mechanism involving factors that tether the centrosome to the nucleus, have been identified.
Title: Suppressors of zyg-1 define regulators of centrosome duplication and nuclear association in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F59E12.11 (e-PCR)
- UniSTS:311305

F59E12.12 (e-PCR)
- UniSTS:311306

F59E12.2 (e-PCR)
- UniSTS:305655

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in activation of mitotic cell cycle spindle assembly checkpoint	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell cycle	IEA Inferred from Electronic Annotation more info
involved_in cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to amino acid starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in centriole replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in centrosome duplication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of temperature stimulus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of translational initiation in response to stress	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of centrosome duplication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitotic cell cycle, embryonic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to kinetochore	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of spindle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell cycle	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of centrosome duplication	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of mitotic cell cycle, embryonic	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of mitotic cytokinetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of protein localization to centrosome	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of spindle assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in reproductive process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spindle assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in centriole	IDA Inferred from Direct Assay more info	PubMed
located_in centriole	IEA Inferred from Electronic Annotation more info
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: putative serine/threonine-protein kinase zyg-1

NP_495103.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

5649748..5654422

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_062702.6 → NP_495103.1 putative serine/threonine-protein kinase zyg-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495103.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O01903, Q9GT24

Conserved Domains (2) summary

smart00220
Location:13 → 249

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:13 → 238

PKc_like; Protein Kinases, catalytic domain