nmy-2 Myosin-11 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: nmy-2
Official Full Name: Myosin-11
Primary source: WormBase:WBGene00003777
Locus tag: CELE_F20G4.3
See related: AllianceGenome:WB:WBGene00003777
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables calmodulin binding activity and protein kinase binding activity. Involved in several processes, including asymmetric protein localization involved in cell fate determination; polarity specification of anterior/posterior axis; and positive regulation of nematode male tail tip morphogenesis. Located in several cellular components, including cleavage furrow; contractile ring; and mitotic spindle. Is expressed in several structures, including QR.a; hypodermal cell; nervous system; neuroblasts; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including auditory system disease (multiple); autosomal dominant Alport syndrome; blood platelet disease (multiple); end stage renal disease; and megacystis-microcolon-intestinal hypoperistalsis syndrome. Orthologous to human MYH10 (myosin heavy chain 10); MYH11 (myosin heavy chain 11); and MYH9 (myosin heavy chain 9). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See nmy-2 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 15

Sequence:: Chromosome: I; NC_003279.8 (7926623..7934577, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Conditional nmy-1 and nmy-2 alleles establish that nonmuscle myosins are required for late Caenorhabditis elegans embryonic elongation.
Title: Conditional nmy-1 and nmy-2 alleles establish that nonmuscle myosins are required for late Caenorhabditis elegans embryonic elongation.
NMY-2, TOE-2 and PIG-1 regulate Caenorhabditis elegans asymmetric cell divisions.
Title: NMY-2, TOE-2 and PIG-1 regulate Caenorhabditis elegans asymmetric cell divisions.
myosin motor activity, but not the ability of myosin to crosslink F-actin, drives ring assembly by compacting and aligning F-actin bundles
Title: Crosslinking activity of non-muscle myosin II is not sufficient for embryonic cytokinesis in C. elegans.
The authors show that nmy-2 does not appear to be involved in generating physical division asymmetry, but nonetheless is important for specifying differential cell fate.
Title: Non-muscle myosin II is required for correct fate specification in the Caenorhabditis elegans seam cell divisions.
asymmetric division found in neuroblast lineage; more myosin II accumulated anteriorly, suggesting asymmetric contractile forces may produce different-sized daughters; balance of myosin on the 2 sides of dividing cell can govern size and fate of daughters
Title: Polarized myosin produces unequal-size daughters during asymmetric cell division.
NMY-2 maintains cellular asymmetry and cell boundaries, and promotes a SRC-dependent asymmetric cell division
Title: NMY-2 maintains cellular asymmetry and cell boundaries, and promotes a SRC-dependent asymmetric cell division.
UNC-45 and NMY-2 are required for fertility since the lack of either component results in complete sterility
Title: UNC-45 is required for NMY-2 contractile function in early embryonic polarity establishment and germline cellularization in C. elegans.
Study concludes that the two pathways of cleavage-furrow formation are mechanistically distinct; in particular, the astral pathway for cleavage-furrow formation involves the negative regulation of myosin distribution by astral cues.
Title: Astral signals spatially bias cortical myosin recruitment to break symmetry and promote cytokinesis.
These results suggest that Galpha signaling and LET-99 control centration by regulating polarized actomyosin contraction.
Title: Control of nuclear centration in the C. elegans zygote by receptor-independent Galpha signaling and myosin II.
Data describe nonmuscle myosins nmy-1 and nmy-2, which are components of the let-502/mel-11 pathway and assist in regulation of embryo elongation in C. elegans.
Title: The Caenorhabditis elegans nonmuscle myosin genes nmy-1 and nmy-2 function as redundant components of the let-502/Rho-binding kinase and mel-11/myosin phosphatase pathway during embryonic morphogenesis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS1-234 (e-PCR)
- UniSTS:241729

F20G4.3 (e-PCR)
- UniSTS:321383

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	IPI Inferred from Physical Interaction more info	PubMed
enables cytoskeletal motor activity	IEA Inferred from Electronic Annotation more info
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microfilament motor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in asymmetric neuroblast division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in asymmetric protein localization involved in cell fate determination	IDA Inferred from Direct Assay more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode larval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in polarity specification of anterior/posterior axis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of nematode male tail tip morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of embryonic cell shape	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cleavage furrow	IDA Inferred from Direct Assay more info	PubMed
located_in contractile ring	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle	IDA Inferred from Direct Assay more info	PubMed
located_in myofibril	IEA Inferred from Electronic Annotation more info
part_of myosin II complex	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin II complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of myosin complex	IEA Inferred from Electronic Annotation more info
is_active_in myosin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in myosin filament	IEA Inferred from Electronic Annotation more info
located_in sarcomere	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Myosin-11

NP_492186.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

7926623..7934577 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059785.10 → NP_492186.3 Myosin-11 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492186.3

Status: REVIEWED

UniProtKB/TrEMBL

G5EBY3, Q22869

Conserved Domains (6) summary

smart00242
Location:81 → 793

MYSc; Myosin. Large ATPases

cd01377
Location:100 → 781

MYSc_class_II; class II myosins, motor domain

pfam00901
Location:1599 → 1865

Orbi_VP5; Orbivirus outer capsid protein VP5

pfam01576
Location:858 → 1934

Myosin_tail_1; Myosin tail

cl03951
Location:1317 → 1396

CDC37_N; Cdc37 N terminal kinase binding

cl21478
Location:1104 → 1195

ATP-synt_B; ATP synthase B/B' CF(0)