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    smgl-2 ATP-dependent RNA helicase DHX34 [ Caenorhabditis elegans ]

    Gene ID: 177135, updated on 9-Dec-2024

    Summary

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    Official Symbol
    smgl-2
    Official Full Name
    ATP-dependent RNA helicase DHX34
    Primary source
    WormBase:WBGene00021365
    Locus tag
    CELE_Y37E11AM.1
    See related
    AllianceGenome:WB:WBGene00021365
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA binding activity and helicase activity. Involved in nuclear-transcribed mRNA catabolic process. Orthologous to human DHX34 (DExH-box helicase 34). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See smgl-2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    11
    Sequence:
    Chromosome: IV; NC_003282.8 (3726164..3735496)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene 3-dehydrosphinganine reductase;3-ketodihydrosphingosine reductase Neighboring gene Ribonuclease P Neighboring gene Anoct_dimer domain-containing protein;Protein XAP5 CIRCADIAN TIMEKEEPER Neighboring gene N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D 2 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mechanistic insights and identification of two novel factors in the C. elegans NMD pathway. Longman D, et al. Genes Dev, 2007 May 1. PMID 17437990, Free PMC Article
    2. DHX34 and NBAS form part of an autoregulatory NMD circuit that regulates endogenous RNA targets in human cells, zebrafish and Caenorhabditis elegans. Longman D, et al. Nucleic Acids Res, 2013 Sep. PMID 23828042, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in nuclear-transcribed mRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ATP-dependent RNA helicase DHX34
    NP_001294374.1
    • Confirmed by transcript evidence
    NP_001368241.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      3726164..3735496
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001307445.3 → NP_001294374.1  ATP-dependent RNA helicase DHX34 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294374.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PRA5
      Conserved Domains (5) summary
      smart00487
      Location:130 → 330
      DEXDc; DEAD-like helicases superfamily
      smart00847
      Location:561 → 635
      HA2; Helicase associated domain (HA2) Add an annotation
      cd00046
      Location:161 → 296
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00271
      Location:350 → 480
      Helicase_C; Helicase conserved C-terminal domain
      pfam07717
      Location:775 → 888
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

    2. NM_001380158.1 → NP_001368241.1  ATP-dependent RNA helicase DHX34 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PEF8
      Conserved Domains (2) summary
      COG1643
      Location:1 → 460
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      pfam07717
      Location:543 → 643
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
    Nucleotide Protein
    Heading Accession and Version

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