Nudc nudC nuclear distribution protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nudcprovided by MGI
Official Full Name: nudC nuclear distribution proteinprovided by MGI
Primary source: MGI:MGI:106014
See related: Ensembl:ENSMUSG00000028851 AllianceGenome:MGI:106014
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SIG-92; Silg92
Summary: Predicted to enable unfolded protein binding activity. Predicted to be involved in several processes, including mitotic metaphase chromosome alignment; mitotic spindle organization; and protein folding. Predicted to be located in cytosol; midbody; and mitotic spindle. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human NUDC (nuclear distribution C, dynein complex regulator). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 117.1), liver E14 (RPKM 77.3) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.3; 4 66.25 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (133259853..133273338, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (133532542..133546027, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NUDC is critical for rod photoreceptor function, maintenance, and survival.
Title: NUDC is critical for rod photoreceptor function, maintenance, and survival.
An essential role of mNUDC for anterograde transport of dynein and dynactin by kinesin-1.
Title: mNUDC is required for plus-end-directed transport of cytoplasmic dynein and dynactins by kinesin-1.
A novel function for mammalian nudC and nudC-like genes as anti-inflammatory proteins.
Title: Isolation and characterization of nudC from mouse macrophages, a gene implicated in the inflammatory response through the regulation of PAF-AH(I) activity.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126527 (e-PCR)
- UniSTS:209667

RH131321 (e-PCR)
- UniSTS:214604

RH125442 (e-PCR)
- UniSTS:162262

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in mitotic metaphase chromosome alignment	ISO Inferred from Sequence Orthology more info
involved_in mitotic metaphase chromosome alignment	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic spindle organization	ISO Inferred from Sequence Orthology more info
involved_in mitotic spindle organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in nuclear migration	IEA Inferred from Electronic Annotation more info
involved_in nuclear migration	ISO Inferred from Sequence Orthology more info
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to peptide hormone	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in midbody	ISS Inferred from Sequence or Structural Similarity more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nuclear migration protein nudC

Names: nuclear distribution gene C homolog; nuclear distribution protein C homolog; silica-induced gene 92 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010948.3 → NP_035078.1 nuclear migration protein nudC

See identical proteins and their annotated locations for NP_035078.1

Status: VALIDATED

Source sequence(s)

AK032673, BE948227, DV652222

Consensus CDS

CCDS18750.1

UniProtKB/Swiss-Prot

O35685, Q3UJS7

Related

ENSMUSP00000030665.7, ENSMUST00000030665.7

Conserved Domains (3) summary

cd06492
Location:173 → 259

p23_mNUDC_like; p23-like NUD (nuclear distribution) C-like domain of mammalian(m) NUDC and similar proteins. Mammalian(m) NUDC associates both with the dynein complex and also with an anti-inflammatory enzyme, platelet activating factor acetylhydrolase I, PAF-AH(I) ...

pfam14050
Location:9 → 60

Nudc_N; N-terminal conserved domain of Nudc

pfam16273
Location:98 → 144

NuDC; Nuclear distribution C domain