gkow-1 G-patch domain and KOW motifs-containing protein homolog 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: gkow-1
Official Full Name: G-patch domain and KOW motifs-containing protein homolog 1
Primary source: WormBase:WBGene00011237
Locus tag: CELE_R11A8.2
See related: AllianceGenome:WB:WBGene00011237
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable nucleic acid binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in nucleus. Predicted to be part of spliceosomal complex. Orthologous to human GPKOW (G-patch domain and KOW motifs). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See gkow-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 5

Sequence:: Chromosome: IV; NC_003282.8 (10358142..10360219)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R11A8.2 (e-PCR)
- UniSTS:307873

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA splicing, via spliceosome	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of spliceosomal complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: G-patch domain and KOW motifs-containing protein homolog 1

NP_501910.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

10358142..10360219

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_069509.3 → NP_501910.1 G-patch domain and KOW motifs-containing protein homolog 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_501910.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q21924

Conserved Domains (3) summary

cd13153
Location:405 → 453

KOW_GPKOW_B; KOW motif of the "G-patch domain and KOW motifs-containing protein" (GPKOW) repeat B

pfam12656
Location:123 → 201

G-patch_2; DExH-box splicing factor binding site

cl00354
Location:225 → 281

KOW; KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese)