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    sid-2 Systemic RNA interference defective protein 2 [ Caenorhabditis elegans ]

    Gene ID: 176805, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sid-2
    Official Full Name
    Systemic RNA interference defective protein 2
    Primary source
    WormBase:WBGene00004796
    Locus tag
    CELE_ZK520.2
    See related
    AllianceGenome:WB:WBGene00004796
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in RNA transport and regulatory ncRNA-mediated post-transcriptional gene silencing. Located in apical plasma membrane and cytoplasm. Is expressed in ciliated neurons; excretory duct; intestine; and in male. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sid-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (13679445..13682450)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Aquaporin Neighboring gene WD repeat-containing protein dyf-2 Neighboring gene Cullin-2 Neighboring gene Peptidyl-prolyl cis-trans isomerase 2 Neighboring gene Serine/threonine kinase NLK Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolution of susceptibility to ingested double-stranded RNAs in Caenorhabditis nematodes. Nuez I, et al. PLoS One, 2012. PMID 22253787, Free PMC Article
    2. Uptake of extracellular double-stranded RNA by SID-2. McEwan DL, et al. Mol Cell, 2012 Sep 14. PMID 22902558, Free PMC Article
    3. SID-2 negatively regulates development likely independent of nutritional dsRNA uptake. Braukmann F, et al. RNA Biol, 2021 Jun. PMID 33044912, Free PMC Article
    4. SID-1 protein of Caenorhabditis elegans mediates uptake of dsRNA into Bombyx cells. Kobayashi I, et al. Insect Biochem Mol Biol, 2012 Feb. PMID 22178129
    5. Caenorhabditis briggsae methods. Baird SE, et al. WormBook, 2006 Dec 18. PMID 18050429, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in RNA transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in RNA transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulatory ncRNA-mediated gene silencing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Systemic RNA interference defective protein 2
    NP_499823.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      13679445..13682450
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067422.7 → NP_499823.2  Systemic RNA interference defective protein 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499823.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EEV9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EEV9.1

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