wago-1 Argonaute protein wago-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: wago-1
Official Full Name: Argonaute protein wago-1
Primary source: WormBase:WBGene00011061
Locus tag: CELE_R06C7.1
See related: AllianceGenome:WB:WBGene00011061
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables DEAD/H-box RNA helicase binding activity. Predicted to be involved in regulatory ncRNA-mediated post-transcriptional gene silencing. Located in P granule. Is expressed in germ line and in male. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See wago-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 9

Sequence:: Chromosome: I; NC_003279.8 (7235384..7238792)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protease-mediated processing of Argonaute proteins controls small RNA association.
Title: Protease-mediated processing of Argonaute proteins controls small RNA association.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R06C7.2 (e-PCR)
- UniSTS:312066

R06C7.1 (e-PCR)
- UniSTS:321616

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DEAD/H-box RNA helicase binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA endonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables miRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables single-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in regulatory ncRNA-mediated gene silencing	IEA Inferred from Electronic Annotation more info
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in P granule	IDA Inferred from Direct Assay more info	PubMed
part_of RISC complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasmic ribonucleoprotein granule	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Argonaute protein wago-1

NP_492045.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

7235384..7238792

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059644.8 → NP_492045.1 Argonaute protein wago-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492045.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q21770

Conserved Domains (3) summary

cd02846
Location:320 → 430

PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...

pfam02171
Location:598 → 905

Piwi; Piwi domain

pfam16486
Location:70 → 166

ArgoN; N-terminal domain of argonaute