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    R148.3 DUF2846 domain-containing protein;DUF4476 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 175423, updated on 9-Dec-2024

    Summary

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    Official Symbol
    R148.3
    Official Full Name
    DUF2846 domain-containing protein;DUF4476 domain-containing protein
    Primary source
    WormBase:WBGene00020102
    Locus tag
    CELE_R148.3
    See related
    AllianceGenome:WB:WBGene00020102
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA binding activity. Predicted to be active in cytoplasm. Is expressed in body wall musculature; neurons; and pharynx. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See R148.3 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    9
    Sequence:
    Chromosome: III; NC_003281.10 (3175331..3183645)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene PID domain-containing protein Neighboring gene MARVEL domain-containing protein Neighboring gene Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5 Neighboring gene MecKel-Gruber Syndrome (MKS) homolog Neighboring gene tRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article
    2. A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding. Lenfant N, et al. BMC Genomics, 2010 Nov 26. PMID 21110867, Free PMC Article
    3. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
    4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    5. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DUF2846 domain-containing protein;DUF4476 domain-containing protein
    NP_001370568.1
    • Confirmed by transcript evidence
    NP_871687.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      3175331..3183645
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_181958.7 → NP_871687.1  DUF4476 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_871687.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8ITY8
      Conserved Domains (5) summary
      PHA01732
      Location:266 → 307
      PHA01732; proline-rich protein
      COG1340
      Location:611 → 937
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      pfam05837
      Location:677 → 753
      CENP-H; Centromere protein H (CENP-H)
      pfam16046
      Location:797 → 950
      FAM76; FAM76 protein
      cl23720
      Location:585 → 684
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    2. NM_001384051.2 → NP_001370568.1  DUF2846 domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KZA5
      Conserved Domains (3) summary
      COG1196
      Location:580 → 904
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5373
      Location:213 → 320
      COG5373; Uncharacterized membrane protein [Function unknown]
      PRK12323
      Location:276 → 477
      PRK12323; DNA polymerase III subunit gamma/tau
    Nucleotide Protein
    Heading Accession and Version

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