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    phac-1 Phosphatase and actin regulator 2 [ Caenorhabditis elegans ]

    Gene ID: 172753, updated on 9-Dec-2024

    Summary

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    Official Symbol
    phac-1
    Official Full Name
    Phosphatase and actin regulator 2
    Primary source
    WormBase:WBGene00009174
    Locus tag
    CELE_F26H9.2
    See related
    AllianceGenome:WB:WBGene00009174
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable actin binding activity. Predicted to be involved in actin cytoskeleton organization. Is expressed in excretory cell; nervous system; and rectal epithelium. Human ortholog(s) of this gene implicated in Parkinson's disease; artery disease (multiple); brain disease (multiple); and multiple sclerosis. Orthologous to several human genes including PHACTR4 (phosphatase and actin regulator 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See phac-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    9
    Sequence:
    Chromosome: I; NC_003279.8 (9289744..9294042, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Phosphotransferase Neighboring gene DNA-directed RNA polymerase I subunit RPA2 homolog Neighboring gene DUF305 domain-containing protein;F-box domain-containing protein Neighboring gene Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 Neighboring gene small monomeric GTPase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cortical domain correction repositions the polarity boundary to match the cytokinesis furrow in C. elegans embryos. Schenk C, et al. Development, 2010 May. PMID 20430749, Free PMC Article
    2. A gateway-compatible yeast one-hybrid system. Deplancke B, et al. Genome Res, 2004 Oct. PMID 15489331, Free PMC Article
    3. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Phosphatase and actin regulator 2
    NP_001412553.1
    • Confirmed by transcript evidence
    NP_001412554.1
    • Confirmed by transcript evidence
    NP_001417602.1
    • Confirmed by transcript evidence
    NP_001417603.1
    • Confirmed by transcript evidence
    NP_001417604.1
    • Confirmed by transcript evidence
    NP_492478.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      9289744..9294042 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001430669.1 → NP_001417603.1  Phosphatase and actin regulator 2 [Caenorhabditis elegans]

      Status: REVIEWED

    2. NM_060077.7 → NP_492478.2  Phosphatase and actin regulator 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492478.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      P91855
      Conserved Domains (1) summary
      smart00707
      Location:392 → 415
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2

    3. NM_001430671.1 → NP_001417604.1  Phosphatase and actin regulator 2 [Caenorhabditis elegans]

      Status: REVIEWED

    4. NM_001430670.1 → NP_001417602.1  Phosphatase and actin regulator 2 [Caenorhabditis elegans]

      Status: REVIEWED

    5. NM_001425624.1 → NP_001412553.1  Phosphatase and actin regulator 2 [Caenorhabditis elegans]

      Status: REVIEWED

    6. NM_001425625.1 → NP_001412554.1  Phosphatase and actin regulator 2 [Caenorhabditis elegans]

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version

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