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    ccb-2 SH3 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 189330, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ccb-2
    Official Full Name
    SH3 domain-containing protein
    Primary source
    WormBase:WBGene00021125
    Locus tag
    CELE_W10C8.1
    See related
    AllianceGenome:WB:WBGene00021125
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable high voltage-gated calcium channel activity. Predicted to be involved in calcium ion transport and chemical synaptic transmission. Predicted to be located in synapse. Predicted to be part of voltage-gated calcium channel complex. Is expressed in head neurons and ventral nerve cord. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ccb-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (2845859..2849903)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene GST C-terminal domain-containing protein;Glutathione S-transferase Neighboring gene arginine kinase Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The alpha1 subunit EGL-19, the alpha2/delta subunit UNC-36, and the beta subunit CCB-1 underlie voltage-dependent calcium currents in Caenorhabditis elegans striated muscle. Lainé V, et al. J Biol Chem, 2011 Oct 21. PMID 21878625, Free PMC Article
    2. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables high voltage-gated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables voltage-gated calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in calcium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of voltage-gated calcium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated calcium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    SH3 domain-containing protein
    NP_001293380.1
    • Partially confirmed by transcript evidence
    NP_001293381.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      2845859..2849903
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001306451.2 → NP_001293380.1  SH3 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293380.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A078BQJ0
      Conserved Domains (1) summary
      cd11863
      Location:99 → 160
      SH3_CACNB; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta

    2. NM_001306452.1 → NP_001293381.1  SH3 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293381.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A078BTJ7
      Conserved Domains (1) summary
      cd11863
      Location:99 → 160
      SH3_CACNB; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta

    RNA

    1. NR_131378.1 RNA Sequence

      Status: REVIEWED

    2. NR_131379.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version

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