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    nlp-14 Neuropeptide-Like Protein [ Caenorhabditis elegans ]

    Gene ID: 181137, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nlp-14
    Official Full Name
    Neuropeptide-Like Protein
    Primary source
    WormBase:WBGene00003752
    Locus tag
    CELE_D1009.4
    See related
    AllianceGenome:WB:WBGene00003752
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable neuropeptide hormone activity. Involved in cellular response to carbon dioxide and negative regulation of nematode pharyngeal pumping. Is expressed in intestine; neurons; and in male. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nlp-14 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    5
    Sequence:
    Chromosome: X; NC_003284.9 (8917423..8919423, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Fibrinogen C-terminal domain-containing protein Neighboring gene ncRNA Neighboring gene Peptidyl-prolyl cis-trans isomerase 8 Neighboring gene tRNA-Gln Neighboring gene ncRNA Neighboring gene Long-chain-fatty-acid--CoA ligase Neighboring gene Tctex1 domain-containing protein 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Orcokinin neuropeptides regulate sleep in Caenorhabditis elegans. Honer M, et al. J Neurogenet, 2020 Sep-Dec. PMID 33044108, Free PMC Article
    2. Monoamines differentially modulate neuropeptide release from distinct sites within a single neuron pair. Clark T, et al. PLoS One, 2018. PMID 29723289, Free PMC Article
    3. The C. elegans male exercises directional control during mating through cholinergic regulation of sex-shared command interneurons. Sherlekar AL, et al. PLoS One, 2013. PMID 23577128, Free PMC Article
    4. Discovery of a cholecystokinin-gastrin-like signaling system in nematodes. Janssen T, et al. Endocrinology, 2008 Jun. PMID 18339709
    5. The response to high CO2 levels requires the neuropeptide secretion component HID-1 to promote pumping inhibition. Sharabi K, et al. PLoS Genet, 2014 Aug. PMID 25101962, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Orcokinin neuropeptides regulate sleep in Caenorhabditis elegans.
      Title: Orcokinin neuropeptides regulate sleep in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables neuropeptide hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to carbon dioxide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of nematode pharyngeal pumping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Neuropeptide-Like Protein
    NP_001257068.1
    • Product from WormBase gene class nlp;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      8917423..8919423 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001270139.5 → NP_001257068.1  Neuropeptide-Like Protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001257068.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18915
    Nucleotide Protein
    Heading Accession and Version

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