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    sid-5 Systemic RNA interference defective protein 5 [ Caenorhabditis elegans ]

    Gene ID: 184450, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sid-5
    Official Full Name
    Systemic RNA interference defective protein 5
    Primary source
    WormBase:WBGene00017445
    Locus tag
    CELE_F14B8.2
    See related
    AllianceGenome:WB:WBGene00017445
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in RNA transport and regulatory ncRNA-mediated post-transcriptional gene silencing. Located in late endosome. Is expressed in several structures, including gonad; intestine; muscle cell; neurons; and somatic cell. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sid-5 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    3
    Sequence:
    Chromosome: X; NC_003284.9 (6904721..6905849)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Secreted protein Neighboring gene ncRNA Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene tRNA-Leu Neighboring gene ncRNA Neighboring gene Sodium/hydrogen exchanger Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The conserved SNARE SEC-22 localizes to late endosomes and negatively regulates RNA interference in Caenorhabditis elegans. Zhao Y, et al. RNA, 2017 Mar. PMID 27974622, Free PMC Article
    2. RNA interference: Systemic RNAi SIDes with endosomes. Rocheleau CE. Curr Biol, 2012 Oct 23. PMID 23098595
    3. Distinct pathways for export of silencing RNA in Caenorhabditis elegans systemic RNAi. Yoshida K, et al. iScience, 2023 Oct 20. PMID 37854694, Free PMC Article
    4. An endomembrane zinc transporter negatively regulates systemic RNAi in Caenorhabditis elegans. Dejima K, et al. iScience, 2023 Jun 16. PMID 37305693, Free PMC Article
    5. Tissue-specific overexpression of systemic RNA interference components limits lifespan in C. elegans. Camara H, et al. Gene, 2024 Feb 15. PMID 37984536

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in RNA transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in RNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulatory ncRNA-mediated gene silencing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in late endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Systemic RNA interference defective protein 5
    NP_509168.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      6904721..6905849
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076767.6 → NP_509168.1  Systemic RNA interference defective protein 5 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509168.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q19443
      Conserved Domains (1) summary
      pfam17204
      Location:2 → 67
      Sid-5; Sid-5 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q19443.1

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