prkl-1 LIM zinc-binding domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: prkl-1
Official Full Name: LIM zinc-binding domain-containing protein
Primary source: WormBase:WBGene00022727
Locus tag: CELE_ZK381.5
See related: AllianceGenome:WB:WBGene00022727
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable zinc ion binding activity. Is expressed in several structures, including QL; egg-laying apparatus; gonad; head; and somatic nervous system. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy 1B. Orthologous to several human genes including PRICKLE2 (prickle planar cell polarity protein 2) and PRICKLE3 (prickle planar cell polarity protein 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See prkl-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 8

Sequence:: Chromosome: IV; NC_003282.8 (6978742..6986935, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

conserved PCP-like pathway consisting of VANG-1/Van Gogh, PRKL-1/Prickle, and DSH-1/Dishevelled is involved in maintaining the polarized morphology of a subset of neurons in the nematode C. elegans.
Title: VANG-1 and PRKL-1 cooperate to negatively regulate neurite formation in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZK381.5 (e-PCR)
- UniSTS:313619

ZK381.6 (e-PCR)
- UniSTS:316297

ZK381.7 (e-PCR)
- UniSTS:316298

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: LIM zinc-binding domain-containing protein

NP_741435.2

Confirmed by transcript evidence

NP_741436.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

6978742..6986935 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_171372.3 → NP_741435.2 LIM zinc-binding domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741435.2

Status: REVIEWED

UniProtKB/TrEMBL

H2KYA1

Conserved Domains (4) summary

cd09340
Location:149 → 204

LIM1_Testin_like; The first LIM domain of Testin-like family

cd09341
Location:210 → 262

LIM2_Testin_like; The second LIM domain of Testin-like family

cd09827
Location:48 → 144

PET_Prickle; The PET domain of Prickle

cl02475
Location:283 → 324

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_171373.6 → NP_741436.2 LIM zinc-binding domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741436.2

Status: REVIEWED

UniProtKB/TrEMBL

A8WFL0

Conserved Domains (3) summary

cd09340
Location:36 → 90

LIM1_Testin_like; The first LIM domain of Testin-like family

cd09341
Location:96 → 148

LIM2_Testin_like; The second LIM domain of Testin-like family

cl02475
Location:169 → 210

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers