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    SEC12 Sar family guanine nucleotide exchange factor SEC12 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855760, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SEC12
    Official Full Name
    Sar family guanine nucleotide exchange factor SEC12
    Primary source
    SGD:S000005309
    Locus tag
    YNR026C
    See related
    AllianceGenome:SGD:S000005309; FungiDB:YNR026C; VEuPathDB:YNR026C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SED2
    Summary
    Enables guanyl-nucleotide exchange factor activity. Involved in regulation of COPII vesicle coating. Located in Golgi apparatus and endoplasmic reticulum. Used to study autism spectrum disorder; cranioectodermal dysplasia; and intellectual disability. Orthologous to human PREB (prolactin regulatory element binding). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SEC12 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (673274..674689, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Snf12p Neighboring gene Mpp6p Neighboring gene putative pyridoxal kinase BUD17 Neighboring gene peptidylprolyl isomerase family protein CPR8

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression, purification, and assay of Sec12p: a Sar1p-specific GDP dissociation stimulator. Barlowe C, et al. Methods Enzymol, 1995. PMID 8583945
    2. Purification, crystallization and preliminary X-ray diffraction analysis of the yeast Sec12Deltap protein, a guanine nucleotide-exchange factor involved in vesicle transport. Dumon-Seignovert L, et al. Acta Crystallogr D Biol Crystallogr, 2001 Jun. PMID 11375521
    3. The yeast Sar exchange factor Sec12, and its higher organism orthologs, fold as beta-propellers. Chardin P, et al. FEBS Lett, 2002 Aug 14. PMID 12163183
    4. A membrane glycoprotein, Sec12p, required for protein transport from the endoplasmic reticulum to the Golgi apparatus in yeast. Nakano A, et al. J Cell Biol, 1988 Sep. PMID 3047151, Free PMC Article
    5. SEC12 encodes a guanine-nucleotide-exchange factor essential for transport vesicle budding from the ER. Barlowe C, et al. Nature, 1993 Sep 23. PMID 8377826

    See all (94) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural basis for the initiation of COPII vesicle biogenesis.
      Title: Structural basis for the initiation of COPII vesicle biogenesis.
    2. The structure of Sec12 implicates potassium ion coordination in Sar1 activation.
      Title: The structure of Sec12 implicates potassium ion coordination in Sar1 activation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of COPII vesicle coating IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of COPII vesicle coating IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sar family guanine nucleotide exchange factor SEC12
    NP_014423.1
    • Guanine nucleotide exchange factor (GEF); activates Sar1p by catalyzing the exchange of GDP for GTP; required for the initiation of COPII vesicle formation in ER to Golgi transport; glycosylated integral membrane protein of the ER; SEC12 has a paralog, SED4, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      673274..674689 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183203.1 → NP_014423.1  TPA: Sar family guanine nucleotide exchange factor SEC12 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014423.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1K0, P11655
      UniProtKB/TrEMBL
      A6ZS99, B3LPL8, C7GLN2, C8ZFQ3, G2WL82, N1P4R6
      Conserved Domains (2) summary
      COG2319
      Location:79 → 335
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:177 → 212
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P11655.1

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