ani-2 Anillin-like protein 2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ani-2
Official Full Name: Anillin-like protein 2
Primary source: WormBase:WBGene00019608
Locus tag: CELE_K10B2.5
See related: AllianceGenome:WB:WBGene00019608
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Involved in several processes, including gonad development; ovulation; and syncytium formation. Located in cytoplasm. Is expressed in germ line. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 8. Orthologous to human ANLN (anillin, actin binding protein). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ani-2 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 12

Sequence:: Chromosome: II; NC_003280.10 (6361159..6365367, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ANI-2 promotes germ cell syncytial organization and allows for compensation of the mechanical stress associated with oogenesis.
Title: C. elegans Anillin proteins regulate intercellular bridge stability and germline syncytial organization.
These results indicate that PAR-4 controls C. elegans embryonic polarity by regulating the activity of anillin family scaffold proteins, thus enabling turnover of cortical myosin and efficient actomyosin contractility.
Title: PAR-4/LKB1 mobilizes nonmuscle myosin through anillin to regulate C. elegans embryonic polarization and cytokinesis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K10B2.3 (e-PCR)
- UniSTS:311519

K10B2.5 (e-PCR)
- UniSTS:311520

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Process	Evidence Code	Pubs
involved_in actomyosin contractile ring assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in multicellular organismal reproductive process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IEA Inferred from Electronic Annotation more info
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ovulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in septin ring organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in syncytium formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in actomyosin contractile ring	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Anillin-like protein 2

NP_495282.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

6361159..6365367 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_062881.4 → NP_495282.1 Anillin-like protein 2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495282.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q09994

Conserved Domains (3) summary

cd01263
Location:892 → 1008

PH_anillin; Anillin Pleckstrin homology (PH) domain

pfam00169
Location:893 → 1004

PH; PH domain

pfam08174
Location:712 → 861

Anillin; Cell division protein anillin