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    ALG12 dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855764, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ALG12
    Official Full Name
    dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase
    Primary source
    SGD:S000005313
    Locus tag
    YNR030W
    See related
    AllianceGenome:SGD:S000005313; FungiDB:YNR030W; VEuPathDB:YNR030W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ECM39
    Summary
    Enables alpha-1,6-mannosyltransferase activity. Involved in dolichol-linked oligosaccharide biosynthetic process. Located in endoplasmic reticulum. Used to study congenital disorder of glycosylation type I. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ig. Orthologous to human ALG12 (ALG12 alpha-1,6-mannosyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ALG12 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (678799..680454)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase family protein CPR8 Neighboring gene GTP-dependent zinc transferase Neighboring gene mitogen-activated protein kinase kinase kinase SSK2 Neighboring gene putative serine/threonine-protein kinase PPG1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hypoglycosylation in the alg12delta yeast mutant destabilizes protease A and causes proteolytic loss of external invertase. Cipollo JF, et al. Glycobiology, 2002 Nov. PMID 12460938
    2. Mutants defective in secretory/vacuolar pathways in the EUROFAN collection of yeast disruptants. Avaro S, et al. Yeast, 2002 Mar 15. PMID 11870858
    3. Degradation of misfolded endoplasmic reticulum glycoproteins in Saccharomyces cerevisiae is determined by a specific oligosaccharide structure. Jakob CA, et al. J Cell Biol, 1998 Sep 7. PMID 9732283, Free PMC Article
    4. ALG12 mannosyltransferase defect in congenital disorder of glycosylation type lg. Grubenmann CE, et al. Hum Mol Genet, 2002 Sep 15. PMID 12217961
    5. Ordered assembly of the asymmetrically branched lipid-linked oligosaccharide in the endoplasmic reticulum is ensured by the substrate specificity of the individual glycosyltransferases. Burda P, et al. Glycobiology, 1999 Jun. PMID 10336995

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables alpha-1,6-mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-1,6-mannosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate derivative biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dolichol-linked oligosaccharide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase
    NP_014427.1
    • Alpha-1,6-mannosyltransferase localized to the ER; responsible for addition of alpha-1,6 mannose to dolichol-linked Man7GlcNAc2; acts in the dolichol pathway for N-glycosylation; human homolog ALG12 complements yeast null mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      678799..680454
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183207.1 → NP_014427.1  TPA: dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014427.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1K4, P53730
      UniProtKB/TrEMBL
      A6ZSA3, B3LPL4, B5VR60, C7GLM8, C8ZFQ7, G2WL86, N1P4S3
      Conserved Domains (1) summary
      cl21590
      Location:8 → 380
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53730.1

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