famk-1 Extracellular serine/threonine protein kinase CeFam20 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: famk-1
Official Full Name: Extracellular serine/threonine protein kinase CeFam20
Primary source: WormBase:WBGene00010356
Locus tag: CELE_H03A11.1
See related: AllianceGenome:WB:WBGene00010356
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables manganese ion binding activity and protein serine/threonine kinase activity. Involved in protein phosphorylation. Predicted to be located in Golgi membrane and extracellular region. Predicted to colocalize with Golgi apparatus. Is expressed in several structures, including body wall musculature; gonad; oocyte; rectum; and vulva. Human ortholog(s) of this gene implicated in amelogenesis imperfecta and amelogenesis imperfecta type 1G. Orthologous to several human genes including FAM20A (FAM20A golgi associated secretory pathway pseudokinase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See famk-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 9

Sequence:: Chromosome: X; NC_003284.9 (15209289..15213259, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

H03A11.1 (e-PCR)
- UniSTS:306432

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables manganese ion binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
colocalizes_with Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Extracellular serine/threonine protein kinase CeFam20

NP_510527.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

15209289..15213259 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078126.5 → NP_510527.1 Extracellular serine/threonine protein kinase CeFam20 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_510527.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9XTW2

Conserved Domains (2) summary

pfam06702
Location:260 → 474

Fam20C; Golgi casein kinase, C-terminal, Fam20

pfam15051
Location:218 → 239

FAM198; FAM198 protein