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    tnt-2 Troponin T [ Caenorhabditis elegans ]

    Gene ID: 181119, updated on 4-Jan-2025

    Summary

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    Official Symbol
    tnt-2
    Official Full Name
    Troponin T
    Primary source
    WormBase:WBGene00006587
    Locus tag
    CELE_F53A9.10
    See related
    AllianceGenome:WB:WBGene00006587
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable tropomyosin binding activity. Predicted to be involved in muscle contraction and sarcomere organization. Predicted to be part of troponin complex. Is expressed in body wall musculature; enteric muscle; and reproductive system. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple) and muscle tissue disease (multiple). Orthologous to human TNNT1 (troponin T1, slow skeletal type); TNNT2 (troponin T2, cardiac type); and TNNT3 (troponin T3, fast skeletal type). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See tnt-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    6
    Sequence:
    Chromosome: X; NC_003284.9 (8721546..8723550, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Zinc transporter Slc39a7 Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Integration of male mating and feeding behaviors in Caenorhabditis elegans. Gruninger TR, et al. J Neurosci, 2006 Jan 4. PMID 16399684, Free PMC Article
    2. Decreased expression of myogenic transcription factors and myosin heavy chains in Caenorhabditis elegans muscles developed during spaceflight. Higashibata A, et al. J Exp Biol, 2006 Aug. PMID 16888068
    3. Review of the results from the International C. elegans first experiment (ICE-FIRST). Adenle AA, et al. Adv Space Res, 2009 Jul 15. PMID 20161164, Free PMC Article
    4. Identification of conserved pathways of DNA-damage response and radiation protection by genome-wide RNAi. van Haaften G, et al. Curr Biol, 2006 Jul 11. PMID 16824923
    5. Caenorhabditis elegans ALG-1 antimorphic mutations uncover functions for Argonaute in microRNA guide strand selection and passenger strand disposal. Zinovyeva AY, et al. Proc Natl Acad Sci U S A, 2015 Sep 22. PMID 26351692, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables tropomyosin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of muscle contraction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sarcomere organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of troponin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of troponin complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Troponin T
    NP_001024703.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      8721546..8723550 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029532.4 → NP_001024703.1  Troponin T [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024703.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7Z072
    Nucleotide Protein
    Heading Accession and Version

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