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    pqbp-1.1 WW domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 176847, updated on 9-Dec-2024

    Summary

    Official Symbol
    pqbp-1.1
    Official Full Name
    WW domain-containing protein
    Primary source
    WormBase:WBGene00020647
    Locus tag
    CELE_T21D12.3
    See related
    AllianceGenome:WB:WBGene00020647
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ribonucleoprotein complex binding activity. Involved in triglyceride metabolic process. Located in nuclear body. Is expressed in several structures, including excretory cell; hypodermis; intestine; nervous system; and reproductive system. Used to study Renpenning syndrome. Human ortholog(s) of this gene implicated in Renpenning syndrome. Orthologous to human PQBP1 (polyglutamine binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See pqbp-1.1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    5
    Sequence:
    Chromosome: IV; NC_003282.8 (259989..261683, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Exonuclease domain-containing protein Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene Paralyzed arrest at two-fold protein 6 Neighboring gene BPTI/Kunitz inhibitor domain-containing protein

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ribonucleoprotein complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in triglyceride metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nuclear body IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    WW domain-containing protein
    NP_499890.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      259989..261683 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067489.5NP_499890.2  WW domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499890.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O16786
      Conserved Domains (1) summary
      smart00456
      Location:90122
      WW; Domain with 2 conserved Trp (W) residues