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    Y46B2A.3 Fibrinogen C-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 189942, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Y46B2A.3
    Official Full Name
    Fibrinogen C-terminal domain-containing protein
    Primary source
    WormBase:WBGene00021578
    Locus tag
    CELE_Y46B2A.3
    See related
    AllianceGenome:WB:WBGene00021578
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be located in membrane. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including biliary tract benign neoplasm; dry eye syndrome; familial juvenile hyperuricemic nephropathy; mucinous adenocarcinoma; and pancreatic cancer (multiple). Orthologous to human MUC1 (mucin 1, cell surface associated). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Y46B2A.3 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    5
    Sequence:
    Chromosome: II; NC_003280.10 (862927..866901, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Methyltransferase FkbM domain-containing protein Neighboring gene UPF0506 domain-containing protein Neighboring gene F-box C protein Neighboring gene ncRNA Neighboring gene Protein argonaute-2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Fibrinogen C-terminal domain-containing protein
    NP_493835.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      862927..866901 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_061434.2 → NP_493835.1  Fibrinogen C-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493835.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N4X3
      Conserved Domains (2) summary
      cd00220
      Location:34 → 170
      VMO-I; Vitelline membrane outer layer protein I (VMO-I) domain, VMO-I is one of the proteins found in the outer layer of the vitelline membrane of poultry eggs; VMO-I, lysozyme, and VMO-II are tightly bound to ovomucin; this complex forms the backbone of the ...
      pfam03762
      Location:34 → 170
      VOMI; Vitelline membrane outer layer protein I (VOMI)
    Nucleotide Protein
    Heading Accession and Version

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