cdc-14 Tyrosine-protein phosphatase cdc-14 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: cdc-14
Official Full Name: Tyrosine-protein phosphatase cdc-14
Primary source: WormBase:WBGene00000383
Locus tag: CELE_C17G10.4
See related: AllianceGenome:WB:WBGene00000383
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables phosphoprotein phosphatase activity. Involved in several processes, including cytoskeleton-dependent cytokinesis; mitotic spindle midzone assembly; and regulation of cell cycle process. Located in microtubule cytoskeleton; midbody; and nucleolus. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 32. Orthologous to several human genes including CDC14A (cell division cycle 14A). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See cdc-14 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 8

Sequence:: Chromosome: II; NC_003280.10 (5589038..5593427, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Control of Cdc14 activity coordinates cell cycle and development in Caenorhabditis elegans.
Title: Control of Cdc14 activity coordinates cell cycle and development in Caenorhabditis elegans.
cdc-14 control developmental cell-cycle arrest in C. elegans.
Title: The CDC-14 phosphatase controls developmental cell-cycle arrest in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C17G10.4 (e-PCR)
- UniSTS:317449

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphoprotein phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in cell cycle	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in dephosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle midzone assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell cycle G1/S phase transition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in polar body extrusion after meiotic divisions	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of G1 to G0 transition	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of G1 to G0 transition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of exit from mitosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of vulval development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in astral microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in intracellular membraneless organelle	IEA Inferred from Electronic Annotation more info
is_active_in kinociliary basal body	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in midbody	IDA Inferred from Direct Assay more info	PubMed
located_in midbody	IEA Inferred from Electronic Annotation more info
is_active_in mitotic spindle	IBA Inferred from Biological aspect of Ancestor more info
located_in mitotic spindle midzone	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in spindle	IDA Inferred from Direct Assay more info	PubMed
located_in spindle	IEA Inferred from Electronic Annotation more info
located_in spindle midzone	IDA Inferred from Direct Assay more info	PubMed
is_active_in spindle pole	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Tyrosine-protein phosphatase cdc-14

NP_001021969.1

Confirmed by transcript evidence

NP_001300510.1

Confirmed by transcript evidence

NP_001367521.1

Confirmed by transcript evidence

NP_001368512.1

Confirmed by transcript evidence

NP_001370451.1

Confirmed by transcript evidence

NP_001379687.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

5589038..5593427 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001026798.8 → NP_001021969.1 Tyrosine-protein phosphatase cdc-14 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021969.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P81299

Conserved Domains (3) summary

COG2453
Location:192 → 347

CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]

pfam14671
Location:23 → 169

DSPn; Dual specificity protein phosphatase, N-terminal half

cl21483
Location:229 → 348

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
NM_001393076.1 → NP_001379687.1 Tyrosine-protein phosphatase cdc-14 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (3) summary

pfam05109
Location:407 → 644

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cd14499
Location:180 → 352

CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins

cd17657
Location:19 → 171

CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins
NM_001383840.2 → NP_001370451.1 Tyrosine-protein phosphatase cdc-14 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (3) summary

pfam05109
Location:407 → 644

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cd14499
Location:180 → 352

CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins

cd17657
Location:19 → 171

CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins
NM_001313581.4 → NP_001300510.1 Tyrosine-protein phosphatase cdc-14 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A0K3AQY3, A0A0K3ATW0, P81299, P81300, Q09955, Q09976, Q6DLY2, Q6DLY3, Q6DLY4, Q6DLY5, Q6DLY6, Q8MQD6

Conserved Domains (3) summary

COG2453
Location:192 → 347

CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]

pfam14671
Location:21 → 170

DSPn; Dual specificity protein phosphatase, N-terminal half

cl25496
Location:410 → 656

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
NM_001381422.2 → NP_001367521.1 Tyrosine-protein phosphatase cdc-14 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (3) summary

pfam05109
Location:465 → 648

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cd14499
Location:180 → 352

CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins

cd17657
Location:19 → 171

CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins
NM_001381423.2 → NP_001368512.1 Tyrosine-protein phosphatase cdc-14 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (3) summary

pfam05109
Location:465 → 662

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cd14499
Location:180 → 352

CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins

cd17657
Location:19 → 171

CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins