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    gln-3 Glutamine synthetase;glutamine synthetase [ Caenorhabditis elegans ]

    Gene ID: 178452, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gln-3
    Official Full Name
    Glutamine synthetase;glutamine synthetase
    Primary source
    WormBase:WBGene00001604
    Locus tag
    CELE_Y105C5B.28
    See related
    AllianceGenome:WB:WBGene00001604
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable glutamine synthetase activity. Predicted to be involved in glutamine biosynthetic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in congenital glutamine deficiency; epilepsy (multiple); heart disease; and neurodegenerative disease (multiple). Orthologous to human GLUL (glutamate-ammonia ligase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gln-3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    5
    Sequence:
    Chromosome: IV; NC_003282.8 (16167781..16170678, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DOT-1.1 (DOT1L) deficiency in C. elegans leads to small RNA-dependent gene activation. Liontis T, et al. BBA Adv, 2023. PMID 37082252, Free PMC Article
    2. Genome-wide microarrray analysis reveals roles for the REF-1 family member HLH-29 in ferritin synthesis and peroxide stress response. Quach TK, et al. PLoS One, 2013. PMID 23533643, Free PMC Article
    3. Caenorhabditis elegans ALG-1 antimorphic mutations uncover functions for Argonaute in microRNA guide strand selection and passenger strand disposal. Zinovyeva AY, et al. Proc Natl Acad Sci U S A, 2015 Sep 22. PMID 26351692, Free PMC Article
    4. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article
    5. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutamine synthetase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutamine synthetase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Glutamine synthetase;glutamine synthetase
    NP_001041009.1
    • Confirmed by transcript evidence
    NP_001041010.1
    • Confirmed by transcript evidence
    NP_001255883.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      16167781..16170678 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001047544.7 → NP_001041009.1  Glutamine synthetase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001041009.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U307
      Conserved Domains (3) summary
      PLN02284
      Location:23 → 366
      PLN02284; glutamine synthetase
      pfam00120
      Location:119 → 373
      Gln-synt_C; Glutamine synthetase, catalytic domain
      pfam03951
      Location:35 → 108
      Gln-synt_N; Glutamine synthetase, beta-Grasp domain

    2. NM_001047545.4 → NP_001041010.1  Glutamine synthetase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001041010.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2HQL4
      Conserved Domains (3) summary
      PLN02284
      Location:20 → 363
      PLN02284; glutamine synthetase
      pfam00120
      Location:116 → 370
      Gln-synt_C; Glutamine synthetase, catalytic domain
      pfam03951
      Location:32 → 105
      Gln-synt_N; Glutamine synthetase, beta-Grasp domain

    3. NM_001268954.3 → NP_001255883.1  glutamine synthetase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255883.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H8ESF5
      Conserved Domains (1) summary
      PLN02284
      Location:3 → 241
      PLN02284; glutamine synthetase
    Nucleotide Protein
    Heading Accession and Version

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